饮水微囊藻毒素污染促肝癌作用实验研究  

Liver Tumor Promoted by Water Polluted with Microcystins on Experimental Hepatocarcinogenesis

作　　者：陈华[1] 孙昌盛[1] 胡志坚[1] 薛常镐[2] 陈铁辉[2] 康天尝 

机构地区：[1]福建医科大学公共卫生学院,福建福州350004 [2]福建省卫生防疫站,福建福州350004 [3]厦门同安区卫生防疫站,福建厦门361000

出　　处：《肿瘤防治杂志》2002年第5期454-456,共3页China Journal of Cancer Prevention and Treatment

基　　金：福建省科技项目 97A114资助

摘　　要：目的 :探讨饮用水低剂量微囊藻毒素对大鼠实验性肝癌形成的促癌作用。方法 :应用二乙基亚硝胺 (DEN)致大鼠肝癌前病变细胞增生灶 (Gamma -谷氨酰转肽酶阳性灶 )发生的短期实验模型研究经饮水摄入低剂量微囊藻毒素的促肝癌作用。结果 :二乙基亚硝胺启动后连续 9周饮用含微囊藻毒素0 5 2 9μg/L的藻培养水 ,大鼠肝Gamma 谷氨酰转肽酶阳性灶数量和面积均出现上升趋势。结论Objective In order to explore the liver tumor promoted activity of drinking microcystins(MC) polluted water on experimental hepatocaroinogenesis.Methods The model for this experiment was a two-stage medium term animal test.After induced by diethylnitrosamine(DEN) initiator the rats drunk MC polluted water (contained MC 0.529 μg/L)9 weeks consistently.The hepatic putative preneoplastic lesions (γ-GT positive foci ) were observed on liver sections.Results The results showed that drinking MC polluted water can enhance both the numbers and areas of γ-GT positive foci in experiment animal.Conclusions This experiment indicated that MC is a liver tumor promoter and its long term effects on hepatocarcinogenesis shouldn't be ignored in drinking water polluted by MC.

关 键 词：促肝癌作用 实验研究 肝肿瘤 微囊藻毒素 Gamma-谷氨酰转肽酶 饮水污染 

分 类 号：R735.7[医药卫生—肿瘤] R73－31[医药卫生—临床医学]