食管鳞状细胞癌中血管生成素样蛋白2的表达及其临床意义  

Angiopoietin-like protein 2 acts as a novel biomarker for diagnosis in patients with esophageal cancer

作　　者：程亮[1] 于裕[1] 张颖[1] 

机构地区：[1]江苏省中医院南京中医药大学附属医院胸外科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2017年第11期1398-1401,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省六大人才高峰项目(2016-WSW-015)

摘　　要：目的:探讨血管生成素样蛋白2(angiopoietin-like protein2,ANGPTL2)在食管鳞状细胞癌(esophageal squamous cell cancer,ESCC)组织中的表达及其临床意义。方法:采用免疫组化检测ESCC组织中ANGPTL2的表达水平;通过酶联免疫吸附法检测食管癌患者和健康对照人群血清中ANGPTL2浓度。结果:与癌旁组织相比,ESCC组织中ANGPTL2的表达明显升高(P<0.001);与健康对照人群相比,食管癌患者血清中ANGPTL2浓度明显升高。通过分析临床数据发现高表达的ANGPTL2与肿瘤体积、淋巴结转移、TNM分期紧密相关。血清ANGPTL2浓度也与淋巴结转移、TNM分期等呈正相关。结论:ANGPTL2在ESCC的增殖和侵袭过程中有重要作用。血清ANGPTL2可以作为诊断ESCC潜在有效的血清标志物。Objective： To detect the expression level of angiopoietin-like protein2（ANGPTL2） in esophageal squamous cell cancer （ESCC） tissues and investigate the clinical value for diagnosis. Metbods：Immunohistoehemistry（IHC） was used to determine the relative ANGPTL2 expression levels in ESCC tissues, and enzyme-linked immunosorbent assays were used to measure the levels of ANGPTL2. Results： Compared with controls, ANGFFL2 expression levels were significantly up-regulated in ESCC tissues and serum （P〈0.001）. Higher expression level of ANGPTL2 was found associated with larger tumor size, more lymph node metastasis and TNM stage. ELISA assay showed that serum ANGFFL2 was significantly elevated in ESCC patients and positively associated with high T-stage, high TNM stage and lymph node metastasis. Conclusion： ANGPTL2 plays a crucial role in proliferation and invasion of ESCC. Serum ANGPTL2 has potential value for early detection of ESCC.

关 键 词：食管鳞状细胞癌 血管生成素样蛋白2 增殖 侵袭 

分 类 号：R735.1[医药卫生—肿瘤]