mTOR信号通路与肝星状细胞功能的关系  

Relationship between mTOR signaling pathway and hepatic stellate cells function

作　　者：彭敏 阳学风[1] 

机构地区：[1]南华大学附属南华医院消化内科,湖南省衡阳市421002

出　　处：《世界华人消化杂志》2017年第35期3141-3148,共8页World Chinese Journal of Digestology

基　　金：国家自然科学基金;No.81373465~~

摘　　要：肝星状细胞(hepatic stellate cells,HSCs)的活化被普遍认为是形成肝纤维化的中心环节.各种因素可通过多种信号通路来调节HSCs的功能,其中哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路是重要的一条通路.因此,深入研究mTOR信号通路与HSCs增殖、凋亡、自噬、衰老的关系,可为临床上肝纤维化的治疗提供新的靶点及方法.本文就mTOR信号通路与HSCs功能关系的研究进展作一综述.The activation of hepatic stellate cells（HSCs） is generally considered to be the central link in the formation of hepatic fibrosis. Various factors can regulate the function of HSCs through multiple signaling pathways, of which the mammalian target of rapamycin（mTOR） signaling pathway is especially important. Elucidating the relationship between the mTOR signaling pathway and the proliferation, apoptosis, autophagy, and senescence of HSCs can provide new therapeutic targets and methods for the clinical treatment of hepatic fibrosis. This paper discusses the relationship between the mTOR signaling pathway and the function of HSCs.

关 键 词：哺乳动物雷帕霉素靶蛋白 肝星状细胞 肝纤维化 

分 类 号：R575.2[医药卫生—消化系统]