胃食管反流病患者血清5-HT、CGRP和SP的表达及其临床意义  

Expressions and clinical significance of 5-HT,CGRP and SP in patients with gastroesophageal reflux disease

作　　者：崔秀芳 王颖[1] 王惠 赵君宁[1] 

机构地区：[1]江苏省省级机关医院消化内科,江苏省南京市210024

出　　处：《江苏医药》2017年第24期1779-1781,共3页Jiangsu Medical Journal

基　　金：江苏省省级机关医院院级课题面上项目(L201407)

摘　　要：目的探讨胃食管反流病患者血清5-羟色胺(5-HT)、降钙素基因相关肽(CGRP)和P物质(SP)的表达及其临床意义。方法 56例胃食管反流病患者中,反流性食管炎(RE)患者32例(RE组),非糜烂性胃食管反流病(NERD)患者22例(NERD组),Barrett食管患者2例(因例数少而剔除)。选取健康体检者36例作为对照组。采用ELLSA法检测5-HT、CGRP和SP的表达。结果与对照组比较,NERD组和RE组患者血清5-HT和CGRP水平升高(P<0.05);NERD组患者血清5-HT水平高于RE组(P<0.05);三组患者血清SP水平差异无统计学意义(P>0.05)。胃食管反流病患者中,腹痛26例,无腹痛28例,腹痛患者血清5-HT水平高于无腹痛患者(P<0.01)。结论胃食管反流病患者中5-HT和CGRP水平较高,且5-HT水平与患者腹痛有关。Objective To investigate the expressions and clinical significance of5-hydroxytryptamine（5-HT）,calcitonin gene-related peptide（CGRP）and P substance（SP）in the patients with gastroesophageal reflux disease.Methods Of 56 cases with gastroesophageal reflux disease（including 2 cases with Barrett esophagus）,32 cases were with reflux esophagitis（group RE）,22 cases were with non-erosive gastrcosophageal reflux disease（group NERD）.The healthy people（36 cases）were selected as the controls（group C）.The expressions of 5-HT,CGRP and SP were detected by ELISA.Results Compared to group C,serum levels of 5-HT and CGRP were higher in groups of NERD and RE（P〈0.05）.Serum level of 5-HT was higher in group NERD than that in group RE（P〈0.05）.There was no significant difference in SP among three groups（P〈0.05）.Of the patients with gastroesophageal reflux disease,26 cases were with abdominal pain and 28 cases without abdominal pain.Serum level of 5-HT was higher in the patients with abdominal pain than that in those without abdominal pain（P〈0.01）.Conclusion The expressions of 5-HT and CGRP are higher in the patients with gastroesophageal reflux disease.Serum level of 5-HT is related to abdominal pain of the patients with gastroesophageal reflux disease.

关 键 词：胃食管反流病 5-羟色胺 降钙素基因相关肽 

分 类 号：R571[医药卫生—消化系统]