妇科门诊6091例HPV感染及其基因型分布  

Human papillomavirus infection and its genotype distribution in 6091 women of gynecologic clinic

作　　者：褚福营[1] 陈相[1] 陶国华[1] 葛熙[1] 范玉平[1] 曹兴建[1] 

机构地区：[1]南通市第一人民医院检验科,江苏省226600

出　　处：《江苏医药》2017年第24期1790-1792,共3页Jiangsu Medical Journal

摘　　要：目的分析南通市某医院妇科门诊女性HPV感染及其基因型分布。方法收集南通市某医院2015—2017年妇科门诊6091例女性宫颈脱落细胞标本,采用PCR-反向点杂交法对23种HPV基因型进行检测,并分析其流行病学特点。结果 6091例就诊女性中共检测出1784例感染者,阳性率为29.29%(1784/6091)。<21岁组感染率为53.45%(31/58),61岁~组感染率为48.33%(29/60)。单一型感染率为65.13%(1162/1784),其中,单一高危型的感染率为50.90%(908/1784),多重感染率为34.87%(622/1784)。高危型HPV总的感染率为24.78%(1509/6091),低危型为9.30%(565/6091)。外阴炎、宫颈炎和宫颈上皮内瘤变患者的HPV感染率分别为57.50%(23/40)、31.07%(472/1519)和41.18%(7/17)。HPV感染最高的前5位基因型分别为52型、16型、58型、81型和53型。结论该院门诊女性HPV的感染率为29.29%,以单一高危型感染为主,<21岁和61岁~为两个感染高峰年龄段。HPV 52型、16型、58型、81型和53型为主要的感染亚型。Objective To analyze the human papillomavirus（HPV）infection and its genotype distribution in the 6091 women of gynecologic clinic of a hospital of Nantong.Methods From 2015 to2017,6091 cervical exfoliated cell specimens were collected from women in a hospital gynecologic clinic of Nantong,which were examined with PCR reverse dot blot for 23 kinds of HPV genotypes.The epidemiological characters were analyzed.Results A total of 1784 HPV positive cases was detected with a HPV infection rate of 29.29%（1784/6091）,which was 53.45%（31/58）for the age group of21 years,48.33%（29/60）for the age group of more than 61 years old.The infection rate of signal HPV genotype was 65.13%（1162/1784）and that of single high risk HPV infection was 50.90%（908/1784）and multiple HPV infection was 34.87%（622/1784）.The infection rate of high risk HPV was 24.78%（1509/6091）and that of low risk HPV was 9.30%（565/6091）.The infection rate of HPV was 57.50%（23/40）in the women with vulvitis,31.07%（472/1519）in those with cervicitis,and 41.18%（7/17）in those with cervical intraepithelial neoplasia.The top five HPV genotypes were52,16,58,81 and 53.Conclusion The overall infection rate of HPV is 29.29% for the women in gynecologic clinic of a hospital of Nantong.Single high risk HPV infection is the most common type.The women aged 21 years old and more than 61 years old are sensitive to HPV infection.The most popular HPV genotypes are HPV 52,16,58,81 and 53.

关 键 词：人乳头瘤病毒 基因型 

分 类 号：R737[医药卫生—肿瘤]