阿莫西林与甲硝唑联合西吡氯铵含漱液治疗单纯性牙周炎患者的疗效及安全性  

Efficacy and safety analysis of amoxicillin and metronidazole combined with cetylpyridinium chloride rinse in the treatment of simple periodontitis

作　　者：郭昌昱 

机构地区：[1]西山煤电(集团)有限责任公司职工总医院口腔科,太原030053

出　　处：《中国实用医刊》2017年第22期102-105,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨阿莫西林与甲硝唑联合西吡氯铵含漱液治疗单纯性牙周炎患者的疗效及安全性。方法选取单纯性牙周炎患者99例，按照随机数字表法分组，对照组49例予以阿莫西林＋甲硝唑治疗，观察组50例给予阿莫西林＋甲硝唑＋西吡氯铵含漱液治疗。比较两组临床疗效、牙周指标[牙周探诊深度（PD）、探诊出血指数（BOP）、临床附着丧失（CAL）、前牙覆盖]及炎症因子[白细胞介素-6（IL-6）、白细胞介素-14（IL-14）]、淀粉蛋白A（SAA）水平，并统计两组不良反应发生率及生活质量（SF-36）评分。结果①临床疗效：观察组治疗总有效率为92.00%（46/50），高于对照组[77.55%（38/49）]，差异有统计学意义（P〈0.05）；②牙周指标：治疗8周后观察组前牙覆盖、PD、BOP及CAL均小于对照组，差异有统计学意义（P〈0.05）；③SAA及炎症因子：治疗8周后观察组血清IL-6、IL-14及SAA水平均低于对照组，差异有统计学意义（P〈0.05）；④不良反应：观察组不良反应发生率为14.00%（7/50），对照组为8.16%（4/49），差异未见统计学意义（P〉0.05）；⑤生活质量：治疗8周后观察组SF-36评分高于对照组，差异有统计学意义（P〈0.05）。结论阿莫西林与甲硝唑联合西吡氯铵含漱液可改善单纯性牙周炎患者炎症反应、牙周组织环境及生活质量，疗效显著，安全性高。Objective To investigate the efficacy and safety of amoxicillin and metronidazole combined with cetylpyridine chloride rinse in the treatment of simple periodontitis.MethodsNinety-nine patients with simple periodontitis were divided into control group （n=49） and observation group （n=50） according to random number table method, the control group was treated with amoxicillin ＋ metronidazole and the observation group were treated with amoxicillin＋ metronidazole＋ cetylpyridinium chloride rinse. The clinical efficacy, periodontal indexes [periodontal exploration depth （BOP）, clinical attachment loss （CAL）, anterior teeth coverage] and inflammatory factors [interleukin-6 （IL-6）, IL-14], amylin A （SAA） levels were compared between the two groups, and the incidence of adverse reactions and quality of life （SF-36） were statistically analyzed.Results①Clinical efficacy： the total effective rate in the observation group [92.00% （46/50）] was higher than that in the control group [77.55%（38/49）], the difference was significant （P〈0.05）; ② periodontal index： anterior teeth cover, PD, BOP and CAL were smaller than those in the control group after 8 weeks of treatment, the differences were significant （P〈0.05）; ③ sAA and inflammatory factors： the serum IL-6, IL-14 and SAA levels in the observation group were lower than those in the control group after 8 weeks of treatment, the differences were significant （P〈0.05）; ④ adverse reactions： there was no significant difference in the incidence of adverse reactions between the observation group [14.00% （7/50）] and the control group [8.16% （4/49）] （P〉0.05）; ⑤ quality of life： after 8 weeks of treatment, the SF-36 score of the observation group was higher than that of the control group, the difference was significant （P〈0.05）.ConclusionsAmoxicillin and metronidazole combined with cetylpyridinium chloride can improve the inflammatory response, periodontal tissue environment and quality of li

关 键 词：单纯性牙周炎 阿莫西林 甲硝唑 西吡氯铵含漱液 疗效 安全性 

分 类 号：R781.42[医药卫生—口腔医学]