STAT1与肿瘤关系的研究进展与展望  

Progress and Prospect of STAT1 in Tumorigenesis

作　　者：陈鲤群[1,2] 刘国娟[1,2] 

机构地区：[1]福州大学生物科学与工程学院,福州350108 [2]福州大学应用基因组学研究所,福州350108

出　　处：《中国细胞生物学学报》2017年第12期1612-1618,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31500616);福建省教育厅科技一般项目(批准号:JA15093)资助的课题~~

摘　　要：信号转导与转录激活因子(signal transducer and activator of transcription,STAT)是一类参与细胞信号转导的转录因子家族。STAT1是STATs蛋白质家族中重要成员之一,它主要通过酪氨酸激酶信号转导与转录激活因子(Janus associated kinase-STAT,JAK-STAT)信号通路在细胞的生长、分化、增殖及凋亡等过程中发挥重要调控作用。STAT1被普遍认为是一种肿瘤抑制因子,具有抑制细胞生长及促进凋亡的作用。该文就STAT1与肿瘤的关系研究进行综述并展望肿瘤治疗的前景。The STAT（signal transducer and activator of transcription） proteins are transcription factors that mediate cytokine/growth factor signaling. STAT1 is one of the most important members of STAT protein family, which mainly plays important roles in regulating thecell growth, differentiation, proliferation and apoptosis by signaling pathway of JAK-STAT. STAT1 is widely regarded as a tumor suppressor gene because of the function of inhibiting cell growth and promoting apoptosis. This review will summarize the relationship between STAT1 and tumor, and to further propose the prospects of tumor therapy.

关 键 词：STAT1 肿瘤 JAK-STAT1信号通路 凋亡 

分 类 号：R730.2[医药卫生—肿瘤]