乳腺癌患者化疗后焦虑抑郁情绪及年龄对认知功能的影响分析  

Analysis of the effects of anxiety, depression and age on cognitive function in breast cancer patients after chemotherapy

作　　者：戴晓艳[1] 邱涛[2] 廖常菊 卞小容 李敏 罗莉[4] 

机构地区：[1]自贡市第一人民医院普外科,四川自贡643000 [2]自贡市第一人民医院神经内科,四川自贡643000 [3]自贡市第一人民医院护理部,四川自贡643000 [4]自贡市第一人民医院手术室,四川自贡643000

出　　处：《中国医学前沿杂志（电子版）》2017年第10期99-103,共5页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：四川省医学研究与试验发展计划项目(1211680786)

摘　　要：目的探讨乳腺癌患者化疗后焦虑抑郁情绪及年龄对认知功能的影响。方法选取2015年1月至2016年9月于本院化疗的90例乳腺癌患者为研究对象,其中三阴性乳腺癌45例(三阴组),非三阴性乳腺癌45例(非三阴组)。选取本院同期90例健康体检者作为对照(健康对照组)。比较三组研究对象简易精神状况检查(mini-mental state examination,MMSE)评分、回顾性记忆(reptropective memory,RM)问卷、前瞻性记忆(prospective memory,PM)问卷及言语流畅性测验(verbal fluency test,VFT)评分,以及健康者和不同年龄段乳腺癌患者化疗后的MMSE、RM、PM及VFT评分。结果两组乳腺癌患者化疗后MMSE评分均显著低于化疗前(P<0.05),RM和PM评分均显著高于化疗前(P<0.05),VFT评分与化疗前比较均无显著差异(P>0.05)。两组乳腺癌患者化疗后MMSE、RM、PM、VFT评分比较均无显著差异(P>0.05)。乳腺癌患者MMSE评分低于健康者(P<0.05),且RM、PM、VFT评分均显著高于健康者(P<0.05);三阴组和非三阴组中无焦虑抑郁患者的MMSE评分均显著高于有焦虑抑郁患者(P<0.05),且RM、PM、VFT评分均显著低于有焦虑抑郁患者(P<0.05)。随着年龄的增长,乳腺癌患者及健康者的MMSE评分均下降(P<0.05),RM、PM及VFT评分均升高(P<0.05);乳腺癌患者的MMSE评分均低于同年龄段健康者(P<0.05),RM、PM及VFT评分均显著高于同年龄段健康者(P<0.05);同年龄段三阴组与非三阴组患者的MMSE、RM、PM及VFT评分比较均无显著差异(P>0.05)。结论乳腺癌患者化疗后认知功能会有不同程度的下降,合并焦虑抑郁患者的认知功能下降更为明显,且乳腺癌患者的年龄越大,认知功能下降越显著。Objective To investigate the effects of anxiety, depression and age on cognitive function in patients with breast cancer after chemotherapy. Method From January 2015 to September 2016, 90 breast cancer patients who received chemotherapy in our hospital were selected as the research subjects, of which 45 cases were negative breast cancer（three negetive group）, and 45 cases in non three negative breast cancer（non three negative group）. 90 healthy people were selected as control（healthy control group） during the same time. Checked and compared the three groups of subjects mini-mental state examination（MMSE） score, retrospective memory（RM） questionnaire, prospective memory（PM） questionnaire and verbal fluency test（VFT） score, and compared the MMSE, RM, PM and VFT scores among healthy control group and patients with different age of breast cancer after chemotherapy. Result The MMSE scores in the two groups of breast cancer patients after chemotherapy were significantly lower than those before chemotherapy（P〈0.05）, and the scores of RM and PM were significantly higher than those before chemotherapy（P〈0.05）. There were no significant differences in VFT score of the two groups compared with before chemotherapy（P〈0.05）. There were no significant differences in the scores of MMSE, RM, PM and VFT after chemotherapy between the two groups（P〈0.05）. The MMSE score in patients with breast cancer were lower than healthy person（P〈0.05）, and RM, PM, VFT scores were significantly higher than healthy person（P〈0.05）. The MMSE scores of patients with no anxiety and depression in three negetive group and non three negetive group were significantly higher than those in the patients with anxiety and depression（P〈0.05）. With the increasing of age, MMSE scores of breast cancer patients and healthy people were decreased（P〈0.05）, the scores of RM, PM and VFT were increased（P〈0.05）; breast cancer patients＇ MMSE scores were lower than those of the same age of h

关 键 词：乳腺癌 焦虑抑郁 年龄 认知功能 

分 类 号：R737.9[医药卫生—肿瘤]