重复经颅磁刺激对急性脑梗死患者血清白介素-6水平及神经功能康复的影响  

Effects of repetitiously transcranial magnetic stimulation on serum levels of interlenkin-6 and rehabilitation of nerve function in patients with acute cerebral infarction

作　　者：邹春颖[1] 姜晓雪[1] 于凤伟[1] 

机构地区：[1]佳木斯大学附属第一医院神经四科,黑龙江佳木斯154003

出　　处：《感染．炎症．修复》2017年第3期158-160,共3页Infection Inflammation Repair

摘　　要：目的:探讨重复经颅磁刺激(r TMS)对急性脑梗死患者血清白介素-6(IL-6)水平及神经功能康复的影响。方法:选取我院收治的急性脑梗死患者80例,按就诊时间顺序分为两组,每组40例。两组均给予急性脑梗死常规治疗。对照组另给予r TMS假刺激;观察组实施r TMS真刺激,采用医疗专用磁刺激器,线圈直径9 cm,最大磁场强度1.4 T,在磁刺激部位(健侧大脑皮质第一躯体运动区)垂直放置线圈,刺激强度为最大强度的60%,刺激频率1 Hz,每日刺激次数为500次。比较两组患者血清IL-6的变化和神经功能评分。结果:治疗前,两组患者血清IL-6水平和美国国立卫生院卒中量表(NIHSS)评分差异无统计学意义(P>0.05)。治疗后3、7、10 d,观察组IL-6水平、NIHSS评分显著低于对照组,两组比较差异均有统计学意义(P<0.05)。结论:对急性脑梗死患者采用r TMS治疗,可降低血清IL-6水平,加快神经功能恢复,值得应用推广。Objective： To investigate the effects of repetitiously transcranial magnetic stimulation （rTMS） on serum interleukin-6 （IL-6） level and rehabilitation of nerve function in patients with acute cerebral infarction （ACI）. Methods： Eighty patients with ACI admitted in the First Affiliated Hospital of Jiamusi University were divided into two groups according to the time of visit （40 each）. All the patients were treated with routine therapy for ACI. Additionally, patients in control group received sham rTMS stimulation, and those in observation group received rTMS stimulation with appropriative medical magnetic stimulator （coil diameter 9 cm, maximum magnetic field intensity 1.4 T ）. The coil was placed vertically on the first somatic movement area of cerebral cortex of the uninjured side, with 60% of maximum magnetic field intensity and frequency of stimulation 1 Hz, 500 times per day. Changes of serum IL-6 levels and neurological function score （NIHSS） were compared between the two groups. Results： There was no statistical significance in serous IL-6 level and NIHSS score between the two groups before treatment （P〉0.05）. On the 3rd, 7th and 10th day after treatment, the serous IL-6 level and NIHSS score were significantly lower in observation group than in control group with significant differences （P〈0.05）. Conclusions： rTMS may decrease the serous IL-6 level, accelerate the recovery of nerve function in patients with ACI, so is worthy of application.

关 键 词：白细胞介素-6 脑梗死 急性 重复经颅磁刺激 

分 类 号：R743.33[医药卫生—神经病学与精神病学]