利培酮合并氟西汀治疗难治性强迫症对照研究  

A comparative study on the efficacy of combining visperidone and fluoxetine in the treatment of refractory obsessive compulsive disorder

作　　者：杨立忠[1] 解昌国 潘玉凤[1] 樊立凤 何颖[1] 

机构地区：[1]泰安市精神卫生中心,山东泰安271021

出　　处：《中国行为医学科学》2002年第4期402-403,共2页Chinese Journal of Behavioral Medical Science

摘　　要：目的　探讨利培酮合并氟西汀对治疗难治性强迫症的疗效。方法　将符合CCMD 2 R强迫症诊断标准的病人 6 0例 ,随机分组 ,实验组 2 8例 ,采用利培酮合并氟西汀治疗。对照组 32例 ,氟西汀治疗 ,疗程 8周。应用耶鲁布朗强迫量表 (Y BOCS)和药物副反应量表 (TESS)于疗前、疗后 2、4、6、8周末评价其疗效及副反应。结果　利培酮合并氟西汀治疗难治性强迫症疗效优于单用氟西汀 (P <0 .0 5 )起效快 ,副作用两组 6、8周末评分比较无显著性差异 (P >0 .0 5 )。Objective To explore the efficacy of combining risperidoe and fluoxetine in the treatment of refractory obsessive compulsive disorder. Methods 60 refractory obsessive compulsive patients who met the criteria of CCMD 2 R were divided into the combination group(28cases) and the single group(32cases) randomly.The former was treated with risperidone and fluoxetine.the latter was treated with fluoxetine.The period of the trail was 8weeks.The efficacy and the side effects were evaluated by Y BOCS and TESS respectively.Results The efficacy was better in the combination group than in the single group (P<0.05).The side effects in the study group was almost the same as that in fluoxetine group.Conclusion Combining risperidone and fluoxetine is a practical way to treat efractory obsessive compulsive disorder.

关 键 词：利培酮 氟西汀 治疗 难治性强迫症 对照研究 

分 类 号：R749.7[医药卫生—神经病学与精神病学]