应用Cox模型分析119例膀胱癌患者术后预后因素  

Application of Cox Proportional Hazard Model to Analyze Postoperative Prognostic Factors of Patients with Bladder Cancer

作　　者：王一哲 黄后宝[1] 

机构地区：[1]皖南医学院弋矶山医院泌尿外科,安徽芜湖241001

出　　处：《沈阳医学院学报》2018年第1期23-25,29,共4页Journal of Shenyang Medical College

摘　　要：目的:探讨影响膀胱癌患者术后预后的相关因素。方法:回顾性分析119例2008年1月至2011年6月在我院手术治疗的膀胱癌患者的临床资料。收集可能影响膀胱癌患者术后预后的相关因素,采用Log-rank检验进行单因素分析,用Cox模型进行多因素分析。结果:随访期为60个月。Cox多因素分析结果显示淋巴结转移(OR=3.0,95%CI:1.1~7.9,P=0.025)、组织学类型(OR=2.7,95%CI:1.2~5.9,P=0.013)、肾积水(OR=2.6,95%CI:1.3~5.3,P=0.008)、临床分期(OR=2.5,95%CI:1.2~5.2,P=0.018)是影响膀胱癌患者术后预后的独立因素。结论:膀胱癌患者术后预后的独立影响因素包括淋巴结转移情况、膀胱癌组织学类型、是否合并肾积水、膀胱肿瘤临床分期。Objective:To explore the prognostic factors of bladder cancer after operation. Methods:The clinical data of 119 patients with bladder cancer treated in our hospital from Jan 2008 to Jun 2011 were retrospectively analyzed to evaluate the postoperative prognostic factors. Log-Rank test was used in univariable analysis. A multivariable analysis was performed by the Cox proportional hazard model. Results:The follow-up period was 60 months. The results of Cox proportional hazard model analysis showed that lymph node metastasis(OR=3.0,95%CI:1.1-7.9,P=0.025),histological types(OR=2.7,95%CI:1.2-5.9,P=0.013),hydronephrosis(OR=2.6,95%CI:1.3-5.3,P=0.008),tumor staging(OR=2.5,95%CI:1.2-5.2,P=0.018) were the independent prognostic factors of the bladder cancer patients. Conclusion: The lymph node metastasis, histological types,hydronephrosis and clinical tumor staging are independent prognostic factors of bladder cancer.

关 键 词：膀胱癌 预后 Cox比例风险分析 

分 类 号：R737.14[医药卫生—肿瘤]