真核细胞翻译起始因子-4E在食管癌变过程中的表达变化及意义  

Expression changes and significance of eukaryocyte initiation factors-4E in esophageal carcinogenesis

作　　者：于建[1] 张景航[1] 杨晓煜[2] 李劲松[1] 狄文玉[1] 臧丹 苏蔚[1] 

机构地区：[1]新乡医学院第一附属医院病理科,河南卫辉453100 [2]新乡医学院病理学教研室,河南新乡453003

出　　处：《新乡医学院学报》2017年第12期1073-1075,共3页Journal of Xinxiang Medical University

基　　金：河南省科技厅科技发展计划项目(编号:082300450150)

摘　　要：目的研究真核细胞翻译起始因子-4E(e IF-4E)在正常食管上皮及不同食管病变组织中的表达及其与血管内皮生长因子(VEGF)的关系。方法从新乡医学院第一附属医院病理科2014年3月至2016年3月胃镜活组织检查存档标本中选取正常食管断端30例、非典型增生32例、原位癌20例和浸润癌117例。采用免疫组织化学法检测e IF-4E、VEGF在各种食管组织中的表达,并分析二者之间的相关性。结果正常食管上皮、非典型增生、原位癌和浸润癌组织中e IF-4E阳性表达率分别为0.0%(0/30)、9.4%(3/32)、45.0%(9/20)和80.3%(94/117)。正常食管上皮与非典型增生组织中e IF-4E阳性表达率比较差异无统计学意义(P>0.05);其余各组织之间两两比较差异均有统计学意义(P<0.05)。117例浸润癌组织中,发生转移和未发生转移癌组织中e IF-4E阳性表达率分别为93.2%(55/59)、67.2%(39/58),发生转移癌组织中的阳性表达率显著高于未发生转移癌组织(P<0.05);浸润至浅肌层、深肌层和外膜的癌组织中e IF-4E阳性表达率分别为70.0%(28/40)、73.8%(31/42)、100.0%(35/35),浸润至浅肌层与深肌层的癌组织中e IF-4E阳性表达率比较差异无统计学意义(P>0.05),浸润至浅肌层和深肌层的食管癌组织中e IF-4E阳性表达率明显低于浸润至外膜的食管癌组织(P<0.05)。食管浸润癌组织中e IF-4E表达与VEGF表达呈正相关(χ~2=51.460,P<0.05)。结论 e IF-4E在正常食管上皮癌变及癌变后的浸润与转移中发挥着重要作用;e IF-4E在食管癌组织中的表达与VEGF有相关性。Objective To explore the expression of eukaryocyte initiation factors-4 E（ e IF-4 E） in normal esophageal epithelium and different esophageal lesions tissue and its relationship with vascular endothelial growth factor（ VEGF）. Methods Thirty normal esophageal incisal margin tissues,32 atypical hyperplasia tissues,20 carcinoma in situ tissues and 117 esophageal invasive carcinoma tissues were selected from the biopsy specimens of the Department of Pathology,the First Affiliated Hospital of Xinxiang Medical University from March 2014 to March 2016. The expression of e IF-4 E and VEGF were detected by immunohistochemistry method and the correlation between them was analyzed. Results The positive expression rate of e IF-4 E in normal esophageal epithelium,atypical hyperplasia,carcinoma in situ and invasive carcinoma tissues was 0. 0%（ 0/30）,9. 4%（ 3/32）,45. 0%（ 9/20） and 80. 3%（ 94/117） respectively. There was no statistic difference in the positive expression rate of e IF-4 E in normal esophageal epithelium and atypical hyperplasia tissues（ P 0. 05）; there was statistic difference in the positive expression rate of e IF-4 E in the other esophageal tissues（ P 0. 05）. In 117 invasive carcinoma tissues,the positive expression rate of e IF-4 E in metastatic carcinoma tissues（ 93. 2%,55/59） was significantly higher than that in the non metastatic carcinoma tissues（ 67. 2%,39/58）（ P 0. 05）. The positive expression rate of e IF-4 E in esophageal carcinoma tissues which invaded into shallow muscle layer,deep muscular layer and adventitia was 70. 0%（ 28/40）,73. 8%（ 31/42） and 100. 0%（ 35/35） respectively; there was no statistic difference in positive expression rate of e IF-4 E in the carcinoma tissues which invaded into shallow muscle layer and deep muscular layer（ P 0. 05）; the positive expression rate of e IF-4 E in the carcinoma tissues which invaded into shallow muscle layer and deep muscular layer was significantly lower than that in the carcinoma tissues which

关 键 词：食管癌 真核细胞翻译起始因子 血管内皮生长因子 

分 类 号：R735.1[医药卫生—肿瘤]