肿瘤间质比在三阴性乳腺癌患者预后评估中的价值  

Value of tumor-stroma ratio in evaluating the prognosis of patients with triple-negative breast cancer

作　　者：路娜 古吉敏[1] 闵志波 

机构地区：[1]宜宾市第二人民医院病理科,四川宜宾644000

出　　处：《新乡医学院学报》2017年第12期1089-1092,共4页Journal of Xinxiang Medical University

摘　　要：目的探讨肿瘤间质比(TSR)在三阴性乳腺癌(TNBC)患者预后评估中的价值。方法选择2010年1月至2014年12月宜宾市第二人民医院收治的TNBC患者87例,采用苏木精-伊红染色法评估TSR,以TSR<50%为间质丰富组,≥50%为间质稀少组。应用COX回归模型分析TNBC患者无瘤生存率和总体生存率的影响因素,采用Kaplan-Meier法进一步分析TSR对TNBC患者无瘤生存率和总体生存率的影响。结果 87例TNBC患者中,TSR≥50%者38例(间质稀少组),TSR<50%者49例(间质丰富组)。87例TNBC患者的5 a无瘤生存率和总体生存率分别为52.9%(46/87)、56.3%(49/87)。单因素COX回归分析显示,肿瘤直径分期、淋巴结转移、肿瘤个数、TSR与TNBC患者的总体生存率和无瘤生存率有显著相关性(P<0.05)。多因素COX回归模型分析显示,肿瘤直径分期、淋巴结转移、肿瘤个数、TSR是TNBC患者总体生存率和无瘤生存率的独立危险因素(P<0.05)。Kaplan-Meier生存分析显示,间质稀少组TNBC患者的5 a无瘤生存率和总体生存率分别为68.4%(26/38)、73.7%(28/38),间质丰富组TNBC患者的5 a无瘤生存率和总体生存率分别为40.8%(20/49)、42.9%(21/49)。Log-Rank检验显示,间质稀少组TNBC患者总体生存率和无瘤生存率显著高于间质丰富组(χ~2=7.788、9.799,P<0.05)。结论 TSR与TNBC患者预后有显著相关,是TNBC患者预后的独立危险因素,可作为TNBC患者评估预后的一项指标。Objective To investigate the value of tumor-stroma ratio（ TSR） in evaluating the prognosis of patients with triple-negative breast cancer（ TNBC）. Methods A total of 87 patients with TNBC were selected from January 2010 to December 2014 in the Second People＇s Hospital of Yibin. The TSR was detected by Hematoxylin eosin staining,the patients with TSR 50% were included in the stroma-rich group,and the patients with TSR≥50% were included in the stroma-rare group.The influencing factors of tumor-free survival and overall survival in TNBC patients were analyzed by COX regression model.The effect of TSR on tumor-free survival and overall survival in TNBC patients was further analyzed by Kaplan-Meier method.Results Among the 87 TNBC patients,there were 38 patients with TSR≥50%（ stroma-rare group） and 49 patients with TSR 50%（ stroma-rich group）. The 5-year tumor-free survival rate and overall survival rate of the 87 TNBC patients was52. 9%（ 46/87） and 56. 3%（ 49/87） respectively. Single factor COX regression analysis showed that the tumor diameter staging,lymph node metastasis,the number of tumors and TSR were significantly correlated with the overall survival rate and tumor-free survival rate of patients with TNBC（ P 0. 05）. Multivariate COX regression analysis showed that the tumor diameter staging,lymph node metastasis,the number of tumors and TSR were independent risk factors for overall survival rate and tumor-free survival rate of patients with TNBC（ P 0. 05）. Kaplan-Meier survival analysis showed that the tumor-free survival rate and the overall survival rate of TNBC patients in the stroma-rare group were 68. 4%（ 26/38） and 73. 7%（ 28/38）,and they were 40. 8%（ 20/49） and 42. 9%（ 21/49） in the stroma-rich group. The Log-Rank test showed that the overall survival rate and disease-free survival rate of the TNBC patients in the stroma-rare group were significantly higher than those in the stroma-rich group（ χ~2= 7. 788,9. 799; P 0. 05）. Conclusion TSR is signi

关 键 词：肿瘤间质比 三阴性乳腺癌 预后 

分 类 号：R737.9[医药卫生—肿瘤]