甲状腺微小乳头状癌组织中Bax、nm23蛋白的表达及临床意义  

Expression and clinical significance of Bax and nm23 protein in papillary thyroid microcarcinoma tissues

作　　者：顾桂源 王维格 黄山[3] 

机构地区：[1]江苏省南通大学附属海安医院病理科,江苏南通226600 [2]复旦大学附属肿瘤医院病理科,上海200032 [3]苏州大学附属第一医院病理科,江苏苏州215000

出　　处：《中国医药导报》2017年第36期29-32,F0003,共5页China Medical Herald

基　　金：江苏省卫生厅医学科研计划资助项目(H201569)

摘　　要：目的研究甲状腺微小乳头状癌(PTMC)组织中B淋巴细胞瘤-2相关X蛋白(Bax)、肿瘤转移抑制基因23(nm23)蛋白的表达及临床意义。方法选择2016年5月~2017年5月在南通大学附属海安医院接受手术治疗的PTMC患者的组织石蜡标本103例记为观察组,将术中切除的距离肿瘤组织≥5 cm的癌旁组织石蜡标本103例记为对照组,另选同期在医院接受手术治疗的甲状腺腺瘤(TA)患者100例记为TA组,检测并对比各组Bax及nm23蛋白的表达,分析观察组Bax及nm23蛋白的表达与其病理参数的关系,以及Bax与nm23蛋白的相关性。结果观察组和TA组Bax蛋白的阳性表达率均分别明显高于对照组,差异均有统计学意义(均P<0.05)。观察组nm23蛋白的阳性表达率均明显高于TA组和对照组,差异均有统计学意义(均P<0.05)。观察组有淋巴结转移的患者Bax及nm23蛋白的阳性表达率均分别明显低于无淋巴结转移者,差异均有统计学意义(均P<0.05)。根据Spearman法对相关性分析后发现,Bax与nm23蛋白的表达呈正相关(r=0.617,P<0.05)。结论 PTMC组织中Bax和nm23蛋白表达均明显升高,且与淋巴结转移有关,此二者关系紧密,可作为监测靶点,有助于评价PTMC患者的病情及预后。Objective To study the expression and clinical protein （Bax）, tumor metastasis suppressor gene 23 （nm23） significance of B lymphocyte tumor associated -2 related X protein in papillary thyroid microcarcinoma （PTMC） tissues. Methods One hundred and three paraffin specimens of PTMC patients who was given surgery treatment in Haian Affiliated Hospital to Nantong University from May 2016 to May 2017 were selected as observation group, the resection of the tumor was ≥ 5 cm far from paraffin embedded specimens of 103 cases of tumor adjacent tissues selected was as control group, another 100 patients with thyroid adenoma （TA） who was given surgery at the same time were chosen and enrolled as TA group, the expression of Bax and nm23 protein in each group was detected and compared, the relationship between the expression of Bax and rim23 protein and pathological parameters in the observation group was analyzed, and the correlation between Bax and nm23 protein was analyzed. Results The positive expression rates of Bax protein in the observation group and the TA group were significantly higher than the control group, and the differences were statistically significant （P 〈 0.05）. The positive expression rate of nm23 protein in the observation group was significantly higher than the TA group and the control group, and the differences were statistically significant （P 〈 0.05）. The positive expression rates of Bax and nm23 protein in the observation group with lymph node metastasis were significantly lower than without lymph node metastasis, and the differences were statistically significant （P 〈 0.05）. According to the correlation analysis of Spearman, it was found that the expression of Bax was positively correlated with the expression of nm23 protein （r = 0.617, P 〈 0.05）. Conclusion The expression of Bax and nm23 protein in PTMC tissues increased significantly,it is closely related to lymph node metastasis and both two indexes can be used as a monitoring target to evaluate the condi

关 键 词：甲状腺微小乳头状癌 组织 BAX NM23蛋白 表达 临床意义 

分 类 号：R736.1[医药卫生—肿瘤]