肝脏局灶性结节性增生的临床病理分析  

Clinicopathologic analysis of liver focal nodular hyperplasia

作　　者：白瑞珍[1] 何玉洁[2] 徐莉 浦勇[1] 

机构地区：[1]江南大学附属医院病理科,江苏无锡214062 [2]江南大学附属医院影像科,江苏无锡214062

出　　处：《中国当代医药》2017年第36期13-15,23,共4页China Modern Medicine

基　　金：江苏省无锡市卫生计生委(原无锡市医院管理中心)青年项目(YGZXQ1302)

摘　　要：目的探讨肝脏局灶性结节性增生(FNH)的临床病理学特点、病因、治疗及预后。方法收集2013年5月~2017年8月我院收治的5例FNH患者的临床资料,观察其病理学形态及免疫组化染色,并结合国内外最新文献对该病变的特点进行总结分析。结果典型的FNH大体有特征性的中央瘢痕,镜下见肿块由结节状增生的肝细胞构成,结节内肝细胞呈1~2层排列,结节间由杂乱的纤维分隔,肝细胞无明显异型。不典型FNH需要与肝细胞腺瘤、肝细胞癌鉴别。结论 FNH是一种少见的良性病变,临床切除后,预后良好。Objective To explore the clinicopathologic character,pathogen,treatment and prognosis of liver focal nodular hyperplasia （FNH）.Methods The cIinical data of 5 patients with FNH of the liver from May 2013 to August 2017 in our hospital were collected.The pathological morphology and immunohistochemical staining were observed.The clinical fea- tures of FNH were analyzed by review of the latest foreign and chinese literature.Reslults Macroscopically,characteris- tic center scar was found in classic type of FNH.Microscopically,nodes composed of heptocytes without atypia weres di- vided by fibrosis septa.The liver plate was consisted of one or two layer of hepatocyts.Non-classical type of FNH should be distinguished from hepatic adenoma and highly differentiated hepatic cancer.Conclusion FNH was a rare benign le- sion occurred in liver,which had good prognosis after clinical excision.

关 键 词：肝局灶性结节性增生 肝细胞腺瘤 肝细胞癌 

分 类 号：R575[医药卫生—消化系统]