超声引导下经皮射频消融治疗恶性肿瘤肝转移  

Ultrasound-guided percutaneous radiofrequency ablation in treatment of liver metastases of malignant tumor

作　　者：林淑芝[1] 徐倩[1] 武金玉[1] 严昆[2] 吴薇[2] 

机构地区：[1]哈尔滨市第一医院超声科,黑龙江哈尔滨150010 [2]北京大学肿瘤医院暨北京市肿瘤防治研究所超声科恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142

出　　处：《中国介入影像与治疗学》2018年第1期29-32,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：哈尔滨市自然科学基金(2009RFQQS019)

摘　　要：目的探讨超声引导下经皮射频消融(RFA)治疗恶性肿瘤肝转移的应用价值。方法回顾性分析2009年12月—2015年5月于我院接受超声引导下经皮RFA治疗的109例恶性肿瘤肝转移患者的临床及影像学资料。结果 109例肝转移癌患者中,单发31例(31/109,28.44%),多发78例(78/109,71.56%);肝转移病灶来源于结直肠、肺、乳腺、胃、胰腺、卵巢及前列腺的恶性肿瘤。共198个肝转移癌病灶中,直径<3cm者151个(151/198,76.26%),直径≥3cm者47个(47/198,23.74%)。治疗后1个月,187个(187/198,94.44%)病灶完全灭活,11个(11/198,5.56%)病灶存在残余活性。与治疗前比较,治疗后1个月患者肿瘤标志物指标明显改善(P均<0.05)。术中及术后并发症发生率6.42%(7/109)。结论对于非手术适应证恶性肿瘤肝转移患者,超声引导下经皮RFA治疗相对安全、有效,短期内可局部控制肝内转移癌的活性。Objective To investigate the application value of ultrasound-guided percutaneous radiofrequency ablation （RFA） in treatment of liver metastases of malignant tumor. Methods Clinical and imaging data of 109 patients with liver metastases of malignant tumor who underwent ultrasound-guided percutaneous RFA during December 2009 to May 2015 were retrospectively analyzed. Results There were 31 patients （31/109, 28.44%） with single liver metastases and 78 pa- tients （78/109, 71.56o//oo） with multiple lesions. The primary tumors included colorectal, lung, breast, gastric, pancreatic, ovarian and prostate carcinomas. Among all 198 liver metastases, there were 151 （151/198, 76.26%） with diameter 3 cm and 47 （47/198, 23.74%） with diameter ≥3 cm. One month after RFA, 187 lesions （187/198, 94.44%） were com- pletely inactivated, while the other 11 lesions （11/198, 5.56%） still had residual activity. One month later, the tumor markers improved obviously compared with those before treatment （all P〈0.05）. The incidence of intraoperative and post- operative complications was 6.42% （7/109）. Conclusion Ultrasound-guided percutaneous RFA is a safe and effective treatment for patients with non-surgical indications of malignant liver metastases, which can partially control the survival activity of liver metastases.

关 键 词：超声检查 导管消融术 肝 肿瘤转移 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]