肝癌射频消融后肝脓肿的发生率及危险因素分析  

Incidence and risk factors of liver abscess after radiofrequency ablation for liver cancer

作　　者：王凇[1] 郝艳红[1,2] 杨薇[1] 吴薇[1] 严昆[1] 李荣杰[1] 张仲一[1] 白秀梅[1] 姜彬彬[1] 陈敏华[1] 

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所超声科恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142 [2]山西医科大学第一医院超声科,山西太原030001

出　　处：《中国介入影像与治疗学》2018年第1期37-41,共5页Chinese Journal of Interventional Imaging and Therapy

基　　金：国家自然科学基金(81471768);北京市自然科学基金(81101745)

摘　　要：目的探讨肝癌射频消融(RFA)后肝脓肿形成的发生率及危险因素。方法回顾性分析2000年1月—2016年6月接受RFA治疗的1 643例肝癌患者的资料,包括原发性肝细胞癌(HCC)942例、胆管细胞癌(CCC)31例、转移性肝癌(MLC)670例,采用Logistic回归对影响因素进行分析。结果肝癌RFA治疗后肝脓肿发生率为0.79%(13/1 643)。单因素分析显示,糖尿病史、肝功能Child-Pugh分级、手术史及肿瘤位置与肝癌RFA治疗后肝脓肿形成相关(P均<0.05);多因素分析显示,糖尿病史、手术史及肿瘤位置为肝癌RFA治疗后肝脓肿形成的独立危险因素。结论糖尿病史、手术史、肿瘤位置是影响肝癌RFA治疗后肝脓肿形成的重要因素。Objective To investigate the incidence and risk factors of liver abscess after radiofrequency ablation （RFA） for liver cancer. Methods A retrospective study was performed on 1 643 patients from January 2000 to June 2016. All the patients were diagnosed with hepatocellular carcinoma （HCC, n= 942）, cholangiocellular carcinoma （CCC, n= 31） or me tastatic liver carcinoma （MLC, n= 670）. Univariate and multiple Logistic regression analysis were used to evaluate the risk factors of liver abscess. Results The incidence of liver abscess after RFA was 0.79~ （13/1 643）. Univariate analysis in- dicated that the liver abscess was significantly correlated with the history of diabetic mellitus （DM）, Child-Pugh level, his- tory of surgery and tumor location （all P〈0.05）. Multivariate analysis showed that the history of DM, history of surgery and tumor location were independent risk factors of liver abscess after RFA for liver cancer. Conclusion History of DM, surgery and tumor location are important factors that result in liver abscess after RFA.

关 键 词：导管消融术 肝肿瘤 发病率 危险因素 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]