维吾尔族不同年龄结直肠癌患者临床病理特点及预后研究  

Clinicopathological Features and Associated Factors for Prognosis in Young and Elderly Uygur Colorectal Cancer Patients

作　　者：帕尔哈提.沙依木 艾孜买提.热合木吐拉[1] 赵泽亮[1] 热西达.加帕尔 艾克热木.玉苏甫[1] 

机构地区：[1]新疆医科大学附属肿瘤医院胃肠外科,新疆乌鲁木齐市830011

出　　处：《中国全科医学》2017年第36期4484-4488,共5页Chinese General Practice

基　　金：新疆维吾尔自治区自然科学基金资助项目(2014211C111)

摘　　要：目的分析新疆地区维吾尔族不同年龄结直肠癌(CRC)患者的临床病理特点及预后,为临床提供借鉴。方法选取2005年1月—2010年12月新疆医科大学附属肿瘤医院收治的维吾尔族CRC患者211例,将患者分为青中年组(<60岁)141例与老年组(≥60岁)70例。对患者的一般临床资料[职业、性别、血型、肿瘤部位、肿瘤大小、分化程度、组织学类型、大体类型、T分期、N分期、M分期、TNM分期、癌胚抗原(CEA)]、预后因素(转移、复发情况及手术方式)进行整理,分析青中老和老年CRC患者的病理特点及预后。结果两组患者职业、分化程度、组织学类型、大体类型比较,差异有统计学意义(P<0.05);两组患者其余一般临床资料比较,差异无统计学意义(P>0.05)。两组患者转移部位、手术方式比较,差异有统计学意义(P<0.05)。两组患者转移、复发情况比较,差异无统计学意义(P>0.05)。两组患者生存曲线比较,差异有统计学意义(χ~2=5.815,P=0.016)。结论与维吾尔族老年CRC患者相比,青中年CRC患者具有以中低分化腺癌为主、肿块型居多、肝内转移可能性较大、预后差等特点。Objective To analyze the clinicopathological features and associated factors for prognosis in young and elderly Uygur colorectal cancer（ CRC） patients,in order to offer a reference for clinical practice. Methods A total of 211 Uygur patients with CRC treated in the Affiliated Cancer Hospital of Xinjiang Medical University from January 2005 to December2010,were enrolled and classified into the young group（ n = 141,aged 60 years） and elderly group（ n = 70,aged ≥60 years）. We collected their clinical data [ occupation, gender, blood type, tumor location, tumor size, degree of differentiation,histological type,gross type,T staging,N staging,M staging,TNM staging and CEA and associated factors for prognosis（ metastatic status,recurrence and surgical approach） ] and analyzed the clinicopathological features and prognosis of the two groups. Results The type of occupation,degree of differentiation,histological type,gross type differed significantly between the groups（ P 0. 05）, whereas distribution of gender, blood type, tumor location, tumor size, T staging, N staging,M staging,TNM staging and level of CEA did not（ P 0. 05）. The distribution of metastatic site and surgical approach was found to be significantly different in two groups,while the prevalence rates of metastasis and local recurrence were not（ P 0. 05）. There was also a significant difference in the survival curve between the young and elderly groups（ χ~2=5. 815,P = 0. 016）. Conclusion Compared with elderly Uygur patients with CRC,young Uygur CRC patients are more likely to have moderately and poorly differentiated colorectal adenocarcinoma, mass type CRC, higher possibilities of intrahepatic metastasis and poor prognosis.

关 键 词：结直肠肿瘤 维吾尔族 老年人 青年人 病理状态 体征和症状 预后 

分 类 号：R735.34[医药卫生—肿瘤]