7-羟基-香豆素硝基衍生物的合成及抑菌活性  

Synthesis and Antifungal Activity of Nitro-derivatives of 7-Hydroxy-coumarin

作　　者：魏艳[1] 邵兴燕 郝双红[1] 

机构地区：[1]青岛农业大学化学与药学院山东省农业仿生应用工程技术研究中心,山东青岛266109

出　　处：《青岛农业大学学报（自然科学版）》2017年第4期284-287,共4页Journal of Qingdao Agricultural University(Natural Science)

基　　金：国家自然科学基金(31471808)

摘　　要：设计合成了7个7-羟基-香豆素硝基衍生物,以~1H NMR确证了其结构,并以菌丝生长速率法对其抑菌活性进行了测定。合成衍生物中4-甲基-7-羟基-6-硝基-香豆素抑菌活性最强,对苹果腐烂病菌及苹果轮纹病菌的EC50约10mg·L^(-1),4-甲基、7-羟基、6-硝基对香豆素抑菌活性有利。Seven nitro-derivatives of 7-hydroxy-coumarin were designed and synthesized,and their structures were confirmed by 1H NMR.Furthermore,their antifungal activities against the mycelia growth of 4 phytopathogens were examined.Compound 4-methyl-7-hydroxy-6-nitro-coumarin exhibited the highest antifungal activities,with EC50 of about 10 mg·L-1 against the phytopathogens Valsa mali and Physalospora piricola.The results showed that 4-methyl,7-hydroxy and 6-nitro were important to the antifungal activity of coumarin.

关 键 词：4-甲基-7-羟基-6-硝基-香豆素 合成 抑菌活性 

分 类 号：TQ460.3[化学工程—制药化工]