2型神经纤维瘤病患者术后的临床特征与预后分析  

Analysis on clinical features and prognosis of patients with neurofibromatosis type 2 after operation

作　　者：杭军[1] 温大平 王钢[1] 雷超 

机构地区：[1]陕西省西安市第一医院神经外科,710002

出　　处：《中国综合临床》2017年第10期912-917,共6页Clinical Medicine of China

摘　　要：目的 探讨2型神经纤维瘤病（NF2）患者术后的临床特征与预后相关性.方法 分析我院2000—2013年行手术治疗的60例NF2患者术后的临床特征与预后.Cox比例风险回归模型进行变量分析.结果 60例患者随访时间为1~188个月,生存53例（88.3%,53/60）,死亡7例（11.7%,7/60）.单因素分析发现首次出现症状年龄、确诊年龄、颅内脑膜瘤和脊髓肿瘤均与患者预后有关（P均〈0.05）.而性别、遗传因素、皮肤病变、眼部疾病、术后听力水平改善、术后头晕症状缓解均与患者预后无关（P均〉0.05）.伴有脊髓肿瘤或颅内脑膜瘤为NF2患者预后的独立危险影响因素（P值分别为0.042、0.037,95%CI分别为0.021~2.069、0.587~2.543,RR值分别为2.475、3.663）.首次出现症状年龄、确诊年龄、眼部病变是影响脊髓肿瘤和颅内脑膜瘤发生的危险因素（P均〈0.05）.结论 NF2临床症状较多,伴发脊髓肿瘤和颅内脑膜瘤是患者预后不良的重要影响因素.Objective To investigate the correlation between clinical features and prognosis of patients with neurofibromatosis type 2（NF2）after operation.Methods The clinical features and prognosis of sixty patients with neurofibromatosis type 2（NF2）from 2000 to 2013 in Xi′an No.1 Hospital were analyzed.Cox proportional hazards regression model was used for variable analysis.Results The patients were followed up for 1-188 months,53 patients survived（88.3%,53/60）,and 7 patients died（11.7%,7/60）.Single factor analysis showed that the first symptom age,age of diagnosis,intracranial meningioma and spinal cord tumor were related to the prognosis of the patients（P〈0.05）.However,gender,genetic factors,skin lesions,eye diseases, postoperative hearing improvement and relief of dizziness after surgery were not correlated with the prognosis of patients（P〉0.05）.Spinal cord tumors or intracranial meningiomas were the independent risk factors for the prognosis of NF2 patients（P=0.042,0.037,95%CI=0.021-2.069,0.587-2.543,RR=2.475,3.663）.The first symptoms age,age of diagnosis,ocular lesions were the risk factors for the occurrence of spinal cord tumors and intracranial meningiomas（P〈0.05）.Conclusion NF2 has many clinical symptoms,accompanied by spinal cord tumor and intracranial meningioma,which are the important prognostic factors in patients with poor prognosis.

关 键 词：2型神经纤维瘤 脊髓肿瘤 脑膜瘤 听神经瘤 临床特征 预后 

分 类 号：R739.4[医药卫生—肿瘤]