胰岛素样生长因子-1、生长激素与乳腺癌相关性研究  

Study on the relationship between growth hormone、insulin-like growth factor 1 and breast cancer

作　　者：刘保华 万舰[2] 余婉燕 朱彩霞[2] 王琼 黎金钱 陈书恩 韩晖[3] 

机构地区：[1]深圳市罗湖区妇幼保健院,518019 [2]广东省妇幼保健院,广州511400 [3]中国疾病预防控制中心妇幼保健中心,北京100081

出　　处：《中国妇幼卫生杂志》2017年第6期1-5,共5页Chinese Journal of Women and Children Health

基　　金：深圳市科技创新项目(JCYJ20150403142731428);深科技创新[92015]170号

摘　　要：目的通过了解乳腺癌患者的生长激素、胰岛素样生长因子-1水平,探讨胰岛素样生长因子-1与乳腺癌的关系。方法采用病例对照研究,以年龄进行1∶1配比乳腺癌患者和对照组各197例,分析两组一般情况、生长激素、胰岛素样生长因子-1水平与乳腺癌发生的关系。结果生长激素水平比较差异无统计学意义(P>0.05);50岁以下女性胰岛素样生长因子-1病例组与对照组比较差异有统计学意义(P<0.01),50岁以上组比较差异无统计学意义(P>0.01);用1∶1匹配条件Logistic回归分析显示,β=0.137,OR=1.147(P<0.01)。结论胰岛素样生长因子-1水平增高是乳腺癌的危险因素,可作为乳腺癌筛查的指标之一。Objective To explore the relationship between insulin-like growth factor 1 and breast cancer by understanding the level of human Growth Hormone and insulin like growth factor 1 （ IGF 1 ） of breast cancer patients. Methods A 1 ： 1 age matched case-control study was used. In all, 197 breast cancer patients and 197 control women were collected. The general information, growth hormone, and insulin-like growth factor 1 levels of the two groups were analyzed. Results There was no statistically significant difference in the growth hormone levels between the two groups （P 〉 0.05）. There was a statistically significant difference in the insulin-like growth factor 1 of women under 50 years old between the breast patients and the control group （ P 〈 0.01 ）, and there was no statistically significant difference in that of women over 50 years old between the two groups （ P 〉 O. 01 ）. The results of Logistic regression analysis showed that β =0. 137, OR = 1. 147 （P 〈0.01 ）. Conclusion The higher level of insulin-like growth factor 1 is a risk factor for breast cancer. It may be used as one of the indicators of breast cancer screening.

关 键 词：乳腺癌 危险因素 胰岛素样生长因子-1 

分 类 号：R737.9[医药卫生—肿瘤]