Cycloartane triterpenoid and its glucoside isolated from Cassia occidentalis  

作　　者：LI Shi-Fei LI Shun-Lin 

机构地区：[1]Institute of Molecular Science, Shanxi University [2]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences

出　　处：《Chinese Journal of Natural Medicines》2017年第12期950-954,共5页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.31270404,31470427)

摘　　要：In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C(1) and its glucoside, cycloccidentaliside VI(2) were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC_(50) value of 1.44 μmol·L^(-1) and TI(Therapeutic Index) value of 15.59.In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C（1） and its glucoside, cycloccidentaliside VI（2） were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC50 value of 1.44 μmol·L^-1 and TI（Therapeutic Index） value of 15.59.

关 键 词：CYCLOARTANE TRITERPENOID CASSIA OCCIDENTALIS Cycloccidentalic acid C Cycloccidentaliside Ⅵ 

分 类 号：R284.2[医药卫生—中药学] R917[医药卫生—中医学]