南极真菌Aspergillus sp. S-3-62次级代谢产物的研究  

Secondary metabolites from Antarctic-derived fungus Aspergillus sp. S-3-62

作　　者：李云海[1] 卢小玲[1] 于豪冰[1] 刘小宇[1] 

机构地区：[1]第二军医大学海洋生物医药研究中心,基础部生物化学与分子生物学教研室,上海200433

出　　处：《中国海洋药物》2017年第6期23-26,共4页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金项目(41306197,41606173);广东省海洋局公益项目(海洋天然产物化合物库GD2012-D01-001)资助

摘　　要：目的对源于南极真菌Aspergillus sp.S-3-62的次级代谢产物进行研究。方法采用Sephadex LH-20色谱、反相ODS柱色谱、高效液相柱层析等色谱分析方法,对Aspergillus sp.S-3-62发酵液的乙酸丁酯萃取部位进行系统分离。结果分离得到7个单体化合物。结论化合物1~7分别被鉴定为β-carboline(1),N-(2-Hydroxypropanoyl)-2-aminobenzoic acid amide(2),Cyclo-(Pro-8-hydroxy-Ile)(3),Cyclo-(Pro-Ile)(4),2-Acetyl-4(3H)-quinazolinone(5),4-Hydroxyben-zaldehyde(6)和Benzeneacetic acid,2-hydroxy-1-methylpropyl ester(7)。其中化合物7为新天然产物。Objective To investigate the secondary metabolites of Antarctic-derived fungus Aspergillus sp.S-3-62.Methods The fermentation broth of the Aspergillus sp.S-3-62 was isolated by various chromatographic methods,such as Sephadex LH-20 chromatography,reverse phase chromatography and HPLC chromatography.The compounds structure were identified on the basis of 1 H,13 C spectral data,and MS and with the relevant literature.Results Seven known compounds were isolated from the fermentation broth of Aspergillus sp.S-3-62.Conclusion Compounds 1~7 were identified asβ-carboline（1）,N-（2-Hydroxypropanoyl）-2-aminobenzoic acid amide（2）,Cyclo-（Pro-8-hydroxy-Ile）（3）,Cyclo-（Pro-Ile）（4）,2-Acetyl-4（3 H）-quinazolinone（5）,4-Hydroxybenzaldehyde（6）,and Benzeneacetic acid,2-hydroxy-1-methylpropyl ester（7）.Moreover,compound 7 was new natural product.

关 键 词：南极真菌 曲霉属 次级代谢产物 

分 类 号：R914[医药卫生—药物化学]