胃癌患者血清中CEA、CAl25、CA72-4和wnt／β-catenin信号通路表达与患者预后的关系  

Relationship between the expression of CEA,CA125,CA72-4 and wnt/ β signaling pathway in patients with gastric cancer and the prognosis

作　　者：雷振宇 

机构地区：[1]上海市徐汇区大华医院普外科,200237

出　　处：《中国综合临床》2017年第11期969-972,共4页Clinical Medicine of China

摘　　要：目的 探讨胃癌患者血清中CEA、CA125、CA72-4和wnt/β-catenin信号通路表达与患者预后的关系.方法 将我院2015年6月至2016年6月间收治并确诊的85例胃癌患者作为研究对象,检测血清中CEA、CA125、CA72-4表达水平和wnt/β-catenin信号通路表达与患者化疗效果及临床预后的关系.结果 疾病进展（PD）、稳定（SD）、部分缓解（PR）、完全缓解（CR）的患者,CEA、CA-125、CA724、wnt、Tcf-4、β-catenin水平比较差异均有统计学意义（F 值分别为28.60、35.50、32.40、33.80、39.50、36.50,P均〈0.05）,且PD患者明显高于SD、PR、CR患者;死亡、转移、复发、稳定的患者,CEA、CA-125、CA724、wnt、Tcf-4、β-catenin 水平比较差异均有统计学意义（F 值分别为28.60、35.50、32.40、33.80、39.50、36.50,P 均〈0.05）;且死亡患者明显高于转移、复发、稳定的患者.wnt（P=0.030）、Tcf-4（P=0.03）、β-catenin（P=0.02）、CA72-4水平（P=0.04）是胃癌患者死亡的独立危险因素.结论 胃癌患者血清中CEA、CA125、CA72-4、wnt/β-catenin信号通路表达与患者预后的密切相关.Objective To investigate the relationship between CEA,CA125,CA72-4 and wnt/ β signaling pathway in the serum of patients with gastric cancer and prognosis.Methods Eighty-five cases with gastric cance treated in Dahua Hospital of Shanghai Xuhui District from June 2015 to June 2016 year served as the research objects,the expression of CEA,CA125,CA72-4 and wnt/ β-catenin signaling pathway were detected and their relationship with the chemotherapy effect and clinical prognosis of the patients was examined.Results There was significant differences in CEA,CA-125,CA724,wnt,Tcf-4,β-catenin level among the progression of the disease（PD）,stable（SD）,partial remission（PR）,complete remission（CR）patients（F=28.60,35.50, 32.40,33.80,39.50,36.50,P〈0.05）.In addition,the levels in PD patients were significantly higher than those in SD,PR,CR patients.In patients with death,metastasis,recurrence,and stabilization,there was significant differences in CEA,CA-125,CA724,wnt,Tcf-4 and β-catenin level（F=28.60,35.50,32.40,33.80,39.50, 36.50,P〈0.05）,Patients with death were significantly higher than those with metastasis,recurrence and stabilizatio.Wnt（P=0.030）,Tcf-4（P=0.03）,β-catenin（P=0.02）and CA72-4 level（P= 0.04）were independent risk factors for death in patients with gastric cancer.Conclusion The expression of CEA,CA125, CA72-4 and wnt/β-catenin signaling pathway in patients with gastric cancer is closely related to the prognosis.

关 键 词：胃癌 CEA CAL25 CA72-4 WNT/Β-CATENIN 预后 

分 类 号：R735.2[医药卫生—肿瘤]