局部晚期头颈部鳞癌同期放疗联合不同含铂方案化疗的回顾性分析  被引量:2

Retrospective analysis of concurrent radiotherapy for locally advanced head and neck squamous cell carcinoma combined with platinum based chemotherapy

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作  者:宁春玉[1] 

机构地区:[1]广西壮族自治区贵港市人民医院肿瘤科,537100

出  处:《中国综合临床》2017年第11期973-976,共4页Clinical Medicine of China

摘  要:目的 观察奈达铂(Nedaplatin,NDP)、奥沙利铂(Oxaliplatin,L-OHP)及顺铂(Cisplatin, DDP)联合放化疗分别对局部晚期头颈部鳞癌的治疗效果.方法 选取我院2012年5月至2017年5月收治的97例局部晚期头颈部鳞癌者进行回顾性分析,患者中33例经NDP+5-Fu(5-氟尿嘧啶,5-Fu) (NDP组)治疗,32例经L-OHP+5-Fu(L-OHP组)治疗,32例经DDP+5-Fu(DDP组)治疗,3组均联合放疗的治疗方案.比较3组的治疗效果和不良反应.结果 NDP组的有效率为78.8%,略高于L-OHP组的75.0%,而DDP组的有效率为62.5%,3组比较差异有统计学意义(χ2=2.365,P=0.031).3组患者在治疗过程中均出现各种不同程度的不良反应,无Ⅳ度不良反应出现.NDP 的各项不良反应的发生率为(49.78 ±3.22)%低于L-OHP组(50.89±3.47)%,L-OHP组低于DDP 组(53.26±4.19)%.但3组比较差异无统计意义(P=0.099).结论 NDP与L-OHP对头颈部鳞癌患都具有较好的疗效,NDP略优于L-OHP.Objective To observe the efficacy of nedaplatin(NDP),Asha Leigh Per(L-OHP)and cisplatin(DDP)combined with radiotherapy and chemotherapy in the treatment of locally advanced head and neck squamous cell carcinoma.Methods The clinical data of ninety-seven cases of locally advanced squamous cell carcinoma of head and neck treated in Guigang City People′s Hospital from May 2012 to May 2017 were retrospectively analyzed.33 cases were treated with NDP+5-Fu(5- fluorouracil,5-Fu)(group NDP),32 cases were treated with L-OHP+5-Fu(group L-OHP),32 cases were treated with DDP+5-Fu(group DDD).The three groups were treated with radiotherapy.Curative effect and adverse reaction of the three groups were compared.Results The results showed that the effective rate of the NDP group was 78.8%,slightly higher than that in the group L-OHP(75.0%)and group DDP(62.5%),the difference among the 3 groups was statistically significant(χ2=2.365,P=0.031).In the course of treatment,there were various degrees of adverse reactions in the three groups,no grade IV adverse reactions occurred.The incidence rate of adverse reactions in group NDP was(49.78±3.22)%,lower than that of group L-OHP(50.89±3.47)%,and that of group L-OHP was lower than that of group DDP(53.26 ± 4.19)%.But the difference among the three groups was not statistically significant(P=0.099).Conclusion NDP and L-OHP have good curative effect on head and neck squamous cell carcinoma,and NDP performs better than L-OHP.

关 键 词:奈达铂 奥沙利铂 顺铂 头颈部鳞癌 

分 类 号:R739.91[医药卫生—肿瘤]

 

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