人乳头状瘤病毒检测进展  

Development of human papillomavirus detection

作　　者：陈玲境 程浩[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院皮肤科,杭州310020

出　　处：《国际流行病学传染病学杂志》2017年第6期411-415,共5页International Journal of Epidemiology and Infectious Disease

摘　　要：HPV是全球最常见的性传播感染病原之一,而持续高危型HPV感染与宫颈癌及癌前病变紧密相关.HPV检测广泛用于HPV感染相关性疾病的自然史和病因学研究,其检测或型别鉴定对HPV感染相关性疾病的筛查、早期诊断、治疗以及预后评估具有重要意义.随着分子生物学、免疫学的不断发展,生物标志物检测逐渐成为HPV检测的研究热点.该文对HPV检测的发展现状及研究进展做一综述.Human papillomavirus （HPV） infection is one of the common sexually transmitted infections worldwide.As is known,persistent high-risk HPV infection is closely related with cervical cancer and precancerous lesions.HPV detection is widely used in the natural history and etiological study of HPV-related diseases.HPV detection or type identification is significant to screening,early diagnosis,treatment and prognosis evaluation of HPV-related diseases.With the development of molecular biology and immunology,biomarker detection has gradually become the researching hotspot.The development status and research progress of HPV detection are reviewed in this article.

关 键 词：乳头状瘤病毒科 核酸分子杂交 PCR 癌蛋白 甲基化 

分 类 号：R737.33[医药卫生—肿瘤]