Recent developments in peptide ligation independent of amino acid side-chain functional group  

作　　者：Jinhua Yang Junfeng Zhao 

机构地区：[1]Key Laboratory of Chemical Biology of Jiangxi Province, College of Chemistry & Chemical Engineering, Jiangxi Normal University

出　　处：《Science China Chemistry》2018年第1期97-112,共16页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (21462023), and the Natural Science Foundation of Jiangxi Province (20143ACB20007, 20153BCB23018)

摘　　要：Chemical synthesis of peptides and proteins has evolved into an indispensable tool for chemical biology. Peptide ligation is a straightforward technique for joining two short peptide fragments together via a native peptide bond to afford a larger natural peptide or protein. However, the junction sites are limited to several specific amino acids because most peptide ligations involve participation of the side-chain functional groups of the junction-site amino acids. To overcome such intrinsic limitations, "general"peptide ligations which do not rely on the side-chain functional group have been developed. This review summarized the recent developments in peptide ligations that are independent of side-chain functional group of ligation-junction-site amino acid.Chemical synthesis of peptides and proteins has evolved into an indispensable tool for chemical biology. Peptide ligation is a straightforward technique for joining two short peptide fragments together via a native peptide bond to afford a larger natural peptide or protein. However, the junction sites are limited to several specific amino acids because most peptide ligations involve participation of the side-chain functional groups of the junction-site amino acids. To overcome such intrinsic limitations, ＂general＂ peptide ligations which do not rely on the side-chain functional group have been developed. This review summarized the recent developments in peptide ligations that are independent of side-chain functional group of ligation-junction-site amino acid.

关 键 词：peptide ligation amide bond formation independent of side-chain functional group amino acid PROTEIN 

分 类 号：N0[自然科学总论—科学技术哲学]