芍药汤加味联合臭氧直肠灌注治疗溃疡性结肠炎大肠湿热证临床研究  

Clinical Study of Modified Shaoyao Tang Combined with Ozone Rectal Perfusion for Ulcerative Colitis with Large Intestine Damp-Heat Syndrome

作　　者：廖衡 石立鹏[1] 张金龙 杨德钱 谭克文 邬红霞 张燕 

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]重庆市垫江县中医院,重庆408300 [3]重庆市垫江县人民医院,重庆408300

出　　处：《新中医》2018年第1期53-56,共4页New Chinese Medicine

基　　金：重庆市卫生局和计划生育委员会资助项目(ZY20150205,2015MSXM195);全国基层名老中医专家传承工作室支持项目(国中药办人教发[2015]25号)

摘　　要：目的:观察芍药汤加味联合臭氧直肠灌注治疗溃疡性结肠炎(UC)大肠湿热证的临床疗效及安全性。方法:将74例UC大肠湿热证患者按随机数字表法分为治疗组和对照组各37例。对照组服用美沙拉嗪肠溶片,治疗组在对照组用药基础上予芍药汤加味内服联合臭氧直肠灌注治疗,30天为1疗程。治疗1疗程后评估中医证候疗效和黏膜病变疗效,观察治疗前后Sutherland疾病活动指数评分的变化。结果:治疗组中医证候疗效优于对照组,差异有统计学意义(Z=-2.038,P=0.042)。治疗组黏膜病变疗效优于对照组,差异有统计学意义(Z=-2.011,P=0.044)。治疗前,2组Sutherland疾病活动指数评分比较,差异无统计学意义(P>0.05)。治疗后,2组Sutherland疾病活动指数评分均较治疗前降低,差异均有统计学意义(P<0.01);治疗组Sutherland疾病活动指数评分较对照组下降更明显,差异有统计学意义(P<0.05)。治疗期间,2组均未发生明显不良反应。结论:在服用美沙拉嗪肠溶片治疗UC大肠湿热证基础上予芍药汤加味内服联合臭氧直肠灌注,能更有效地改善患者的症状体征,提高治疗效果,且安全性高。Objective： To observe the clinical effect and safety of modified Shaoyao tang combined with ozone rectal perfusion for ulcerative colitis（UC） with large intestine damp-heat syndrome.Methods：Divided 74 UC patients with large intestine damp-heat syndrome into the treatment group and the control group randomly according to random number table method,37 cases in each group.Both groups received mesalazine enteric-coated tablets for treatment,while the treatment group additionally received modified Shaoyao tang combined with ozone rectal perfusion.One course of treatment lasted for 30 days.Evaluated the curative effect of the two therapies on Chinese medicine syndrome and mucosal lesions.Observed change of scores of Sutherland disease activity index before and after treatment.Results：The effect on Chinese medicine syndrome in the treatment group was better than that in the control group,the difference being significant（Z=-2.038,P=0.042）.The effect on mucosal lesions in the treatment group was better than that in the control group,the difference being significant（Z=-2.011,P=0.044）.Before treatment,compared scores of Sutherland disease activity index in both groups,there was no significant difference（P〈0.05）.After treatment,scores of Sutherland disease activity index in both groups were lower than those before treatment,differences being significant（P〈0.01）; decrease of the index scores in the treatment group was more evident than that in the control group,difference being significant（P〈0.05）.No obvious adverse reaction was found in both groups during the treatment.Conclusion：On the basis of mesalazine enteric-coated tablets,applying modified Shaoyao tang combined with ozone rectal perfusion for UC patients with large intestine damp-heat syndrome can effectively improve symptoms and body signs of patients as well as enhance the curative effect with high safety.

关 键 词：溃疡性结肠炎(UC) 活动期 大肠湿热证 芍药汤 臭氧 直肠灌注 Sutherland疾病活动指数 

分 类 号：R574.62[医药卫生—消化系统]