血管钙化中成骨样细胞来源及其转化的研究进展  

Research progress of the origin of osteoblast-like cells and phenotypic transition in vascular calcification

作　　者：严泽振[1] 沈玲红[1] 何奔[1] 

机构地区：[1]上海交通大学医学院附属仁济医院心内科,上海市200127

出　　处：《中国动脉硬化杂志》2017年第11期1169-1173,共5页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81370399和91539106)

摘　　要：血管钙化是一种多因素介导、主动、可逆的调节过程,涉及多种细胞因子及信号通路。血管钙化的本质是多种血管细胞成分向成骨样细胞表型转化,最终导致管壁增厚、管腔狭窄和血管硬化重塑。目前研究表明,血管平滑肌细胞、钙化血管细胞、周细胞以及血管壁内的间充质干细胞都具有向成骨样细胞表型转化的潜能。成骨样细胞的来源及其转化和促血管钙化机制已成为这一领域的重大研究课题。Vascular calcification is a multi-factor mediated,reversible and active regulation process. It involves a large number of cytokines and signaling pathways. The essence of vascular calcification is an osteoblastic phenotypic shift in some vascular cell types,resulting in vascular wall thickening,lumen stenosis and vascular remodeling. Recent studies have showed that several kinds of vascular cells including vascular smooth muscle cells,calcifying vascular cells,pericytes and mesenchymal stem cells in vascular walls have the potential to differentiate into osteoblast-like phenotype. Therefore,it is important to study the origin of the osteoblast-like cells and the modulation of phenotypic transition related to the vascular calcification.

关 键 词：血管钙化 血管平滑肌细胞 钙化血管细胞 周细胞 间充质干细胞 

分 类 号：R0[医药卫生]