碱性离子液体中吲哚与芳基硫酚的3-芳烃硫基化反应  

Direct 3-Arylsulfenylation of Indoles with Thiols in Basic Ionic Liquid

作　　者：岑竞鹤 杨凯[2] 李建晓 李灿 杨少容[1] 

机构地区：[1]华南理工大学化学与化工学院,广州510640 [2]赣南医学院药学院,赣州341000

出　　处：《有机化学》2017年第12期3213-3219,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21502055;21642005);中央高校基本科研业务费(No.2015ZM150);中国博士后科学基金(No.2016T90779)资助项目~~

摘　　要：无金属条件下,在离子液体[Hemim]N(CN)_2中,实现了吲哚衍生物与芳基硫酚的偶联反应,以中等至优良产率(68%~90%)合成系列芳烃硫基取代的吲哚化合物.其结构均经1H NMR,13C NMR及HRMS确证.该反应具有反应条件温和、底物适用范围广、环境友好等优点.此外,生成的产物通过进一步的修饰与转化可以衍生为结构复杂的、具有潜在生物活性的有机分子骨架结构.An efficient and convenient transition metal-free procedure for the synthesis of 3-sulfenylindoles derivatives in moderate to good yields from readily available indoles and thiols in basic ionic liquid has been developed. Their structures were confirmed by 1 H NMR, 13 C NMR and HRMS. This sulfenylation process provides a novel route for directly accessing 3-sulfenylindoles in good to excellent yields and good functional group tolerance with high atom efficiency. Notably, the current methodology could also be conveniently applied to the synthesis of thioarylated naturally occurring biologically active frameworks.

关 键 词：离子液体 吲哚 硫酚 3-芳烃硫基化反应 

分 类 号：O621.25[理学—有机化学]