银催化9-联烯嘌呤与氟代双(苯磺酰基)甲烷的单氟甲基化反应（英文）  

Ag-Catalyzed Monofluoromethylation of Purin-9-yl Allenes with Fluorobis(phenylsulfonyl)methane

作　　者：郭真[1] 谢明胜 韩瑞杰 渠桂荣[1] 郭海明[1] 

机构地区：[1]河南师范大学化学化工学院,新乡453007

出　　处：《有机化学》2018年第1期112-117,共6页Chinese Journal of Organic Chemistry

基　　金：supported by the National Natural Science Foundation of China(Nos.U1604283,21402041);the Plan for Scientific Innovation Talent of Henan Province(No.164200510008);the China Postdoctoral Science Foundation Funded Project(No.2016M592293);the Program for Innovative Research Team in Science,Technology in University of Henan Province(No.15IRTSTHN003);the Program of Introducing Talents of Discipline to Universities(111 Project,No.D17007)~~

摘　　要：以氟代双(苯磺酰基)甲烷为氟化试剂,AgF(3 mol%)为催化剂,实现了9-联烯嘌呤的单氟甲基化反应,并在不同取代基的9-联烯嘌呤底物中均表现出了较好的收率.单氟甲基化反应具有较高的化学选择性和E-选择性.同时,这种方法为合成含氟嘌呤化合物提供了一种有效的途径.The monofluoromethylation of purin-9-yl allenes with fluorobis（phenylsulfonyl）methane has been achieved. With Ag F（3 mol%） as the catalyst, the fluorobis（phenylsulfonyl）methylated adducts could be afforded in excellent yields. The monofluoromethylation exhibited high chemoselectivities and E-selectivies. Meanwhile, the monofluoromethylation of purin-9-yl allenes with fluorobis（phenylsulfonyl）methane provided a useful route to construct fluorinated acyclic nucleoside analogues.

关 键 词：单氟甲基化反应 9-联烯嘌呤 氟代双(苯磺酰基)甲烷 

分 类 号：O621.251[理学—有机化学]