二苯乙烯苷对大鼠高脂性脂肪肝的治疗作用  

Therapeutic effect of 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside on hyperlipidemic fatty liver in rats

作　　者：赵喜 范晓博 王小蓉 王贵栓 

机构地区：[1]南通大学医学院生殖医学研究院,江苏226001

出　　处：《交通医学》2017年第6期511-514,共4页Medical Journal of Communications

基　　金：南通市科技计划项目(MS12015059)

摘　　要：目的 :探讨二苯乙烯苷(TSG)对大鼠高脂性脂肪肝治疗作用的可能机制。方法 :建立大鼠高脂性脂肪肝模型后,分别给予不同剂量的二苯乙烯苷治疗6周,然后测定各组大鼠血脂、肝脂,肝重系数,以及血清中超氧化物歧化酶(SOD)、丙二醛(MDA)和还原型谷胱甘肽(GSH)水平,同时观察肝脏的病理变化。结果:与模型组相比,TSG给药6周,能显著降低脂肪肝大鼠血清和肝脏中TG和FFA含量,降低肝重系数,并升高血清中SOD和GSH水平,而降低MDA水平。同时病理检查结果显示,TSG各浓度给药组,大鼠肝组织脂肪变性程度明显得到改善。结论:TSG对大鼠实验性脂肪肝具有明显的治疗作用,其机制可能与其抗氧化作用有关。Objective: To explore t he potential mechanisms underlying the therapeutic effect of 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside(TSG) on hyperlipidemic fatty liver in rats.Methods: A rat model with hyperlipidemic fatty liver was established by orally feeding fat milk for 4 weeks.Then TSG was administered to these rats for 6 weeks,the TG and FFA levels in serum and hepatic tissues,hepatic weight coefficient,the levels of superoxide dismutase(SOD),malondialdehyde(MDA)and glutathione(GSH)in serum were measured.Meanwhile,the hepatic histopathological changes were observed.Results:Compared with the model group,the TG and FFA levels in serum and hepatic tissues,hepatic weight coefficient and MDA levels were significantly decreased,while the SOD and GSH levels in serum were increased in the TSG-treated groups.Meanwhile,the histological evaluation of liver specimens revealed that lipid accumulation in the TSG-treated groups were obviously ameliorated.Conclusion: TSG was effective in treating hyperlipidemic fatty liver in rats,and its mechanism might be associated with its antioxidation.

关 键 词：二苯乙烯苷 高脂性脂肪肝 超氧化物歧化酶 丙二醛 还原型谷胱甘肽 

分 类 号：R575.5[医药卫生—消化系统]