阿司匹林联合氟桂利嗪对偏头痛患者血清hs-CRP水平和脑血流速度的影响及效果研究  

Study on the effect of aspirin combined with flunarizine on the level of serum hs-CRP and cerebral blood flow velocity of migraine

作　　者：刘雅芳[1,2] 黄咏梅 匡良洪[1,2] 曹雄彬[1,2] 石云琼 戴军[1] 

机构地区：[1]鄂东医疗集团黄石市中心医院(湖北理工学院附属医院)神经内科,湖北黄石435000 [2]肾脏疾病发生与干预湖北省重点实验室,湖北黄石435000 [3]黄石市疾病预防控制中心,湖北黄石435000

出　　处：《临床和实验医学杂志》2018年第2期152-155,共4页Journal of Clinical and Experimental Medicine

基　　金：黄石市医药卫生科技研究项目(编号2014-11)

摘　　要：目的评价阿司匹林联合氟桂利嗪对偏头痛患者血清超敏C反应蛋白(hs-CRP)水平及脑血流速度的影响。方法前瞻性选取2015年9月至2016年4月就诊的偏头痛患者90例,根据随机数字表法分为两组:口服氟桂利嗪胶囊(对照组,45例)和口服氟桂利嗪联合阿司匹林肠溶片组(联合组,45例)。比较两组患者治疗前后发作频次、持续时间、疼痛强度及疼痛积分。根据治疗后偏头痛各项症状的变化幅度,比较两组患者的临床疗效。采用速度比浊法测定两组患者治疗前和治疗结束后血清hs-CRP水平;两组患者治疗前后进行颅多普勒超声检查,分别监测双侧大脑前动脉(ACA)、大脑中动脉(MCA)、大脑后动脉(PCA)、椎动脉(VA)和基地动脉(BA)的平均血流速度(Vm)。结果与治疗前相比,两组治疗后偏头痛各症状指标明显降低,且组间比较结果显示,联合组各症状评分显著低于对照组,差异有统计学意义(P<0.05)。治疗后联合组的血清hs-CRP水平明显低于治疗前水平,差异有统计学意义(P<0.05)。对照组治疗前后前后血清hs-CRP水平差异无统计学意义(P>0.05)。组间比较显示,治疗后联合组的血清hs-CRP水平显著低于对照组,差异有统计学意义(P<0.05)。两组治疗后脑血流速度各项均显著低于治疗前,差异有统计学意义(P<0.05)。组间比较结果显示,联合组的ACA、MCA、BA的Vm均显著低于对照组,差异有统计学意义(P<0.05)。经为期1个月的治疗后,联合组治疗有效率(91.11%)显著高于对照组(62.22%),差异有统计学意义(P<0.05)。结论阿司匹林联合氟桂利嗪治疗偏头痛能有效缓解症状,控制血清hs-CRP水平,降低脑血流速度,提高治疗有效率,值得临床推广应用。Objective To evaluate the effect of aspirin combined with flunarizine on the level of serum hs-CRP and cerebral blood flow velocity of migraine.Methods From September 2015 to April 2016 in our department,90 cases of migraine patients were randomly divided into two groups,including oral fluoride Cinnarizine Capsules(control group,45 cases) and oral administration of flunarizine combined with Aspirin Enteric-coated Tablets group(combined group,45 cases).The frequency,duration,intensity of pain and pain scores were compared between the two groups before and after treatment.According to the changes of the symptoms of migraine after treatment,the efficacy of the two groups were compared.The serum hs-CRP level was determined by the end of the two groups of patients before and after treatment rate nephelometry,two groups of patients before and after treatment performed transcranial Doppler ultrasonography.Bilateral anterior cerebral artery(ACA),middle cerebral artery(MCA),posterior cerebral artery(PCA),vertebral artery(VA) and base artery(BA) the average blood flow velocity(Vm) were monitored.Results The results showed that,compared with before treatment,the symptom index of the two groups after treatment of migraine group decreased significantly.The symptom score of combined group was significantly lower than that of the control group,the difference was statistically significant(P < 0.05).After treatment,the serum hs-CRP level in the combined group was significantly lower than that of before treatment,the difference was statistically significant(P < 0.05).There was no significant difference in serum hs-CRP level before and after treatment in the control group(P > 0.05).The serum hs-CRP level of the treatment group was significantly lower than that of the control group,the difference was statistically significant(P < 0.05).The cerebral blood flow velocity were significantly lower than that of before treatment,the difference was statistically significant(P < 0.05).ACA,MCA,BA Vm of combined group were significantly lower

关 键 词：偏头痛 阿司匹林 氟桂利嗪 血清HS-CRP水平 脑血流速度 

分 类 号：R747.2[医药卫生—神经病学与精神病学]