新生儿Kasabach-Merritt综合征1例并文献复习  

A Case of Neonate Hemangioma with Kasabach-Merritt Syndrome and Literature Review

作　　者：王小兰[1] 余莉华[1] 张丽娟[1] 林丹娜[1] 巫一立 杨丽华[1] 

机构地区：[1]南方医科大学珠江医院儿科,广东广州510280

出　　处：《中国皮肤性病学杂志》2018年第1期52-54,共3页The Chinese Journal of Dermatovenereology

摘　　要：患儿男,生后1天,出生即发现右侧大腿有一巨大暗红色包块,实验室检查提示血小板减少、低纤维蛋白原血症,彩超提示血管性病变,诊断为Kasabach-Merritt综合征。急性期静脉应用糖皮质激素、长春新碱,后期辅以静滴、局部注射干扰素的序贯内科治疗,治疗2周后血小板及凝血功能恢复正常,总疗程1年4个月,瘤体全部消失,目前遗留皮肤松弛、色素沉着。A newborn male infant of one-day old was born with a relatively big dark red mass in his right thigh.Laboratory test suggesed thrombocytopenia and hypofibrinogenemia, which vascular anomalies was seen by color Doppler USG.It was diagnosed as Kasabach-Merritt syndrome.During acute stage,intravenous injection of glucocorticoids and vincristine was recommended.In the later stage,intravenous injection and local injection of interferon in sequential treatment were used as the maintenance treatment.After two weeks of treatment,the platelet count and coagulation function returned to normal.After 1 year and 4 months treatment, the tumor was completely cured with no relapse.However, the skin laxity and pigmentation still remained.

关 键 词：KASABACH-MERRITT综合征 血管瘤 新生儿 血小板减少 凝血功能紊乱 

分 类 号：R739.5[医药卫生—肿瘤]