SIRT6在心血管疾病中的作用研究进展  

Research progress of SIRT6 in cardiovascular diseases

作　　者：张晓英 张致英 

机构地区：[1]西藏民族大学医学部基础医学院藏药筛选实验室,陕西咸阳712082

出　　处：《中国药理学通报》2018年第2期170-173,共4页Chinese Pharmacological Bulletin

基　　金：西藏自治区科技厅自然基金资助项目(No 2016ZR-MQ-06)

摘　　要：心血管疾病以高发病率、高死亡率的特点成为危害人类健康的严重疾病。SIRT6作为组蛋白去乙酰化酶家族的重要成员,在动脉粥样硬化、心肌梗死以及缺血/再灌注损伤、病理性心肌肥大、心力衰竭等心血管疾病中发挥重要作用。该文主要针对SIRT6在心血管疾病中的作用进行综述,并对以SIRT6为靶点的激动剂和抑制剂的研究做一总结。Cardiovascular disease is a serious disease harmful to human health with high morbidity and high mortality. SIRT6 plays an important role in cardiovascular diseases such as atherosclerosis,myocardial infarction and ischemia/reperfusion injury,pathological cardiac hypertrophy and heart failure,as an important member of the histone deacetylase family. In this paper,the role of SIRT6 in cardiovascular diseases is reviewed,and the development of SIRT6 as a target agonist and inhibitor is summarized.

关 键 词：SIRT6 去乙酰化 动脉粥样硬化 心肌梗死 心肌肥大 激动剂 抑制剂 

分 类 号：R-05[医药卫生] R341.27