ALOX5AP基因SG13S114和SG13S32多态性与中国人缺血性脑卒中关系的Meta分析  

Association of SG13S114 and SG13S32 polymorphisms in ALOX5AP gene and risk of ischemic stroke in Chinese:a meta-analysis

作　　者：戴蕙旭 何俏[1] 李光校[1] 张鹏[1] 孙皓[1] 时景璞[1] 

机构地区：[1]中国医科大学附属第一医院临床流行病学教研室,沈阳110001

出　　处：《中国循证医学杂志》2018年第1期13-20,共8页Chinese Journal of Evidence-based Medicine

摘　　要：目的系统评价ALOX5AP基因SG13S114和SG13S32多态性与中国人缺血性脑卒中的相关性。方法计算机检索Web of Science、EMbase、Pub Med、CNKI、CBM和Wan Fang Data数据库,搜集ALOX5AP基因SG13S114和SG13S32多态性与中国人缺血性脑卒中相关的病例-对照研究,检索时限均从建库至2017年2月。由2名研究者独立筛选文献、资料提取,并评价纳入研究的偏倚风险后,采用Stata 12.0进行Meta分析。结果共纳入20个研究。Meta分析结果显示:ALOX5AP基因SG13S114多态性与中国人缺血性脑卒中发病风险增加具有相关性[A vs.T:OR=1.12,95%CI(1.00,1.27),P=0.05;TA+AA vs.TT:OR=1.14,95%CI(1.01,1.28),P=0.04;AA vs.TT:OR=1.33,95%CI(1.07,1.65),P=0.012]。SG13S32多态性与中国人缺血性脑卒中发病风险不相关。结论 ALOX5AP基因SG13S114多态性与中国人缺血性脑卒中有关,A等位基因是其潜在危险因素。Objectives To investigate the relationship between SG13S114 and SG13S32 polymorphisms in ALOX5AP gene and risk of ischemic stroke in Chinese population. Methods We searched Web of Science, EMbase, PubMed, CNKI, CBM and WanFang Data databases to collect case-control studies on SG13S114 and SG13S32 polymorphisms ofALOX5AP gene and risk ofischemic stroke in Chinese from inception to February 2017. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Meta-analysis was then performed by Stata 12.0 software. Results A total of 20 studies were included. The results ofmeta-analysis showed that S G 13S 114 polymorphism in ALOX5AP gene was associated with risk of ischemic stroke in Chinese （A vs. T： OR= 1.12, 95%CI 1.00 to 1.27, P=0.05; TA＋AA vs. TT： OR=l.14, 95%CI 1.01 to 1.28, P=0.04; AA vs. TT： OR=1.33, 95%CI 1.07 to 1.65, P-=0.012）. However, no significant association between SG13S32 polymorphism and ischemic stroke in Chinese was found. Conclusions SG13S114 polymorphisms in ALOXSAP gene is associated with risk of ischemic stroke in Chinese, in which the A allele of ALOX5AP may be a risk factor.

关 键 词：ALOX5AP 多态性 缺血性脑卒中 META分析 病例-对照研究 

分 类 号：R743.3[医药卫生—神经病学与精神病学]