中国非小细胞肺癌患者时辰化疗疗效及安全性的Meta分析  

Efficacy and security of chronic-chemotherapy in Chinese patients with non-small cell lung cancer: A Meta-analysis

作　　者：彭小东[1] 宋来 

机构地区：[1]成都市第二人民医院肿瘤科,四川成都610017

出　　处：《现代肿瘤医学》2018年第3期364-370,共7页Journal of Modern Oncology

基　　金：中国博士后基金项目和四川省博士后基金项目(编号:2013M542282);四川省青年科技基金项目(编号:2012JQ0051);成都市科技局基金项目(编号:2015-HM01-00275-SF)

摘　　要：目的:总结目前已发表的有关中国非小细胞肺癌患者时辰化疗的临床研究,探讨中国非小细胞肺癌患者时辰化疗的疗效及安全性。方法:在Cochrane Library、Pub Med、中国知网、维普、中国生物医学文献数据库、万方数据库中检索已公开发表的非小细胞肺癌患者时辰化疗的随机对照试验,对符合标准的文献提取相关临床效应指标进行Meta分析。结果:总共纳入29篇研究,Meta分析结果显示:针对中国非小细胞肺癌人群,时辰化疗能明显提高治疗效果,同时显著降低化疗中常见毒副反应的发生(P<0.05)。结论:时辰化疗可以有效提高中国非小细胞肺癌患者近期治疗效果,同时还能减轻多种化疗所致重度毒副反应,是一种值得进一步研究的治疗手段。Objective：To provide the basis for the study of non - small cell lung cancer （NSCLC） chronic - chemotherapy, we summarize the current research on ehronotherapy of NSCLC and clarify the current status of chronic - chemotherapy in Chinese patients with NSCLC. Methods： Randomized controlled trials of published chronic - chemotherapy for NSCLC were retrieved in the databases such as Coehrane Library, PubMed, Embase, CNKI, VIP, CBM and WanFang. Meta - analysis was performed on the clinical data of the eligible literature. Results ： A total of thirty articles were included. The results of meta- analysis showed that chronic - chemotherapy can significantly im- prove the therapeutic effect of Chinese patients with NSCLC as well as reducing a lot of severe side effects caused by chemotherapy. Conclusion：Our study demonstrates that chronic -chemotherapy may represent a promising therapeu- tic method for Chinese patients with NSCLC.

关 键 词：非小细胞肺癌 时辰化疗 META分析 

分 类 号：R734.2[医药卫生—肿瘤]