血清CEACA199 CA125及血浆M2-PK联合检测在胃癌诊断中的临床研究  

Clinical study on joint detection of serum CEA,CA199,CA125 and plasma M2-PK in the diagnosis of gastric cancer

作　　者：钟世洪 成志烜 王卓 

机构地区：[1]万载县人民医院,江西万载336100

出　　处：《基层医学论坛》2018年第1期1-2,共2页The Medical Forum

基　　金：江西省宜春市2017年科技计划指导性项目(JXYC2017KSB032)

摘　　要：目的探讨血清癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原125(CA125)及血浆M2-丙酮酸激酶(M2-PK)联合检测在胃癌诊断中的临床应用价值。方法选择2017年6月—2017年10月我院收治的良性胃病患者30例为A组,选择同期在我院进行体检的健康志愿者30例为B组,30例胃癌患者为C组,分别采用酶联免疫吸附法(ELISA)检测3组M2-PK水平,采用电化学发光法(ECLIA)检测3组CEA、CA199及CA125水平,比较3组相关指标检测结果。结果 C组患者M2-PK、CEA、CA199、CA125水平均明显高于A组与B组,差异具有统计学意义(P<0.05);C组患者M2-PK、CEA、CA199、CA125阳性检出率明显高于A组与B组,差异具有统计学意义(P<0.05);四者联合检测的灵敏度明显高于单独检测,且特异度明显高于CEA、CA125单独检测,差异具有统计学意义(P<0.05)。结论血清M2-PK、CEA、CA199、CA125水平检测对临床诊断胃癌具有较高的辅助价值,且四者联合检测能显著提高诊断的特异性和敏感性。Objective To investigate the clinical application value of joint detection of serum carcino-embryonic antigen （CEA）, carbohydrate antigen 199 （CA199）, carbohydrate antigen 125 （CA125） and plasma M2 pyruvate kinase （M2-PK） in the diagnosis of gastric cancer. Methods 30 patients with benign gastric disorders in our hospital from June 2017 to October 2017 were selected as A group, 30 healthy volunteers with physical examination were selected as B group, and 30 patients with gastric cancer were selected as C group. The levels of plasma M2-PK in three groups were detected by enzyme linked immunosorbent assay （ELISA）. The levels of serum CEA, CA199, CA125 in three groups were detected by electrochemiluminescence immunoassay （ECLIA）. The detection results of related indexes were compared among the three groups. Results The levels of M2-PK, CEA, CA199, CA125 in C group were higher than those in A and B group （P〈O.05）; The positive detection rate of M2-PK, CEA, CA199, CA125 in C group was higher than that in A and B group （P〈0.05） ; The sensitivity of joint detection was higher than that of single detection, and the specificity of joint detection was higher than that of single detection of CEA and CA 125 （P〈0.05）. Conclusion The levels of serum M2-PK, CEA, CA199, CA125 can assist clinical detection of gastric cancer, and joint detection can significantly increase the specificity and sensitivity in the diagnosis of gastric cancer.

关 键 词：胃癌 诊断 CEA CA199 CA125 M2-PK 

分 类 号：R735.2[医药卫生—肿瘤]