阿帕替尼治疗肺巨细胞癌1例并文献复习  

Effects of Apatinib in treatment of lung giant cell carcinoma: A case report and review of literature

作　　者：李巧珍 张才金 王爱民[1] 

机构地区：[1]中国人民解放军第175医院,福建漳州363000

出　　处：《现代肿瘤医学》2018年第4期530-533,共4页Journal of Modern Oncology

摘　　要：目的:探讨肺巨细胞癌的临床特征、诊断和治疗方法。方法:报道1例肺巨细胞癌患者的临床资料并对相关文献进行复习。对肺巨细胞癌的临床特征、影像学表现、病理学特征和治疗方法进行分析。结果:1例肺巨细胞癌患者因刺激性呛咳、左侧胸部闷痛3个月入院。胸部CT检查及病理穿刺活检明确诊断为肺巨细胞癌。采取多西他赛联合顺铂3周方案化疗,化疗2个周期后临床症状轻微好转且疗效评价稳定(SD),化疗4个周期后疗效评价进展(PD),口服阿帕替尼抗肿瘤血管生成治疗后疗效评价亦是PD。结论:肺巨细胞癌临床罕见,生存期短,预后差,目前无标准的治疗方法,化疗可能短暂延缓肿瘤进展,阿帕替尼抗肿瘤血管生成治疗效果可能欠佳。Objective：To investigate the clinical characteristics,diagnosis and treatment of lung giant cell carcinoma.Methods：To report 1 case of lung giant cell carcinoma.Its clinical characteristics,imaging,pathological features and therapeutic effects were analyzed and related literatures were reviewed.Results：1 case of lung giant cell carcinoma patient who was hospitalized because of irritating cough and left chest stuffy pain for 3 months.Chest CT examination and pathological biopsy confirmed the diagnosis of giant cell carcinoma of the lung.The patient received docetaxel and cisplatin chemotherapy per three weeks.Her clinical symptoms slightly relieved after 2 cycles of chemotherapy and objective efficacy evaluation of therapies was stable disease.Objective efficacy evaluation of therapies was progressive disease after 4 cycles of chemotherapy.After anti-angiogenesis therapy with Apatinib,objective efficacy evaluation of therapies was still progressive disease.Conclusion：Lung giant cell carcinoma was very rare,which had a short survival time and poor prognosis.There was no generally accepted standard treatment.The patient received chemotherapy might be feasible to delay the progression of tumor and anti-angiogenesis therapy with Apatinib may be ineffective.

关 键 词：肺巨细胞癌 肺肉瘤样癌 阿帕替尼 抗肿瘤血管生成治疗 

分 类 号：R734.2[医药卫生—肿瘤]