噬血细胞综合征临床特征及预后因素分析  

Analysis of clinical characteristics and prognosis for patients with hemophagocytic syndrome

作　　者：李佩章[1] 王英[1] 庞乃奇 张云[1] 刘妙凤 朱春燕[1] 

机构地区：[1]广西医科大学附属肿瘤医院检验科,广西南宁530021

出　　处：《现代肿瘤医学》2018年第4期597-599,共3页Journal of Modern Oncology

基　　金：广西壮族自治区卫计委科研课题(编号:Z2013421)

摘　　要：目的:分析噬血细胞综合征的临床特征及影响预后因素,旨在进一步提高对该综合征的认识。方法:回顾性分析46例噬血细胞综合征患者的临床表现、实验室检查及转归等资料。结果:存活21例,死亡25例,死亡组肝、脾肿大比存活组明显(P<0.05),血小板(PLT)、纤维蛋白原(FIB)水平明显低于存活组(P<0.05),铁蛋白(SF)、丙氨酸氨基转移酶(ALT)、乳酸脱氢酶(LDH)水平明显高于存活组(P<0.05);年龄、发热、白细胞(WBC)、血红蛋白(Hb)、天门冬氨酸氨基转移酶(AST)比较差异无统计学意义(P>0.05)。结论:噬血细胞综合征临床表现多样,肝脾肿大、PLT降低、FIB降低、SF升高、ALT、LDH升高的患者预后不佳,故早期诊断及时治疗至关重要。Objective：To investigate the clinical characteristics and prognosis for patients with hemophagocytic syndrome（HPS） and to improve recognition of HPS.Methods：46 patients of HPS were continuously collected at our hospital.Their laboratory data,clinical features,therapy and prognosis were analyzed.Results：Of the 46 patients,21 survived and 25 died.Compared with survival group,the size of liver and spleen were significantly enlarged in death group（P〈0.05）,the platelet（PLT） and fibrinogen（FIB） levels were significantly decreased in death group（P〈0.05）,while the lactate dehydrogenase（LDH） ,alanine aminotransferase（ALT）and serum ferritin（SF） levels were significantly increased （P〈0.05）.The other indicators（age,fever,WBC,Hb,AST）exhibited no statistically significance（P〉0.05）.Conclusion：The clinical manifestations of HPS were complex.Patients with enlargement liver or spleen,with declined FIB or PLT levels,with elevated LDH or SF levels have poor prognosis.Diagnose and treat HPS as early as possible are the key to improve prognosis.

关 键 词：噬血细胞综合征 临床特征 治疗 预后 

分 类 号：R737.73[医药卫生—肿瘤]