术前中性粒细胞与淋巴细胞比值对乳腺癌改良根治术预后的影响  

Impact of neutrophil/lymphocytes ratio on the prognosis in breast cancer patients who underwent modified radical mastectomy

作　　者：刘晓丹[1] 吕晨光[1] 秦瑶 张雪峰[1] 

机构地区：[1]沈阳军区总医院普通外科,辽宁沈阳110084

出　　处：《中国现代普通外科进展》2017年第10期757-760,共4页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨术前外周血中性粒细胞/淋巴细胞比值(NLR)对乳腺癌改良根治术患者预后的影响。方法:回顾分析沈阳军区总医院普通外科2002年1月—2005年1月收治的180例行改良根治术的乳腺癌患者的临床资料,根据术前外周血中性粒细胞/淋巴细胞的比值(NLR)分为两组,以NLR=6.0为分界值,采用卡方检验分析NLR与临床病理特征的关系,采用Kaplan-Meier预后曲线和COX回归模型分析NLR与乳腺癌临床病理特征及预后的关系。结果:术前高NLR与乳腺癌肿瘤大小、淋巴结转移、TNM分期相关(P<0.05)。Kaplan-Me ie r预后曲线提示术前高NLR组无进展生存期和总生存期均显著低于低NLR组(P<0.05)。单因素和多因素COX回归分析提示术前高NLR、肿瘤大小、淋巴结转移以及TNM分期与乳腺癌无进展生存期和总生存期显著相关(P<0.05)。结论:术前高NLR是影响乳腺癌改良根治术后生存期的独立危险因素。Objective＇. To purpose of this study is to introduce how peripheral blood neu- trophil/lymphocyte ratio （NLR） before operations influences the prognosis of patients with breast cancer. Methods： Review of systems were used to analyze patients who suffered from breast cancer and accepted modified radical mastectomy of breast cancer according to the clinical data of 180 cases of Shenyang Military Region General Hospital between January 2002 and January 2005. All the patients were classified into two groups according to the NLR with the critical value at 6.0. 2 statistics were used to evaluate the relationship between NLR of two groups and clinical pathological characteristic. Kaplan-Meier survival analysis and Cox＇s proportional hazards regression model were used to analyze the relationship among NLR of two groups, other clinical pathologic characteristic and prognosis of patients. Results： The high level of NLR is related with the size of patients＇ tumor, lymph node metastasis and TNM stages （P〈0.05）. Kaplan-Meier survival curves indicated the group of high level of NLR＇s overall survival （OS） and disease-free survival （DFS） was significantly lower than the low level NLR group （P〈0.05）. Single factor and multivariate cox＇s proportional hazards re- gression model indicated the high level of NLR before operations, the size of tumor, lymph node metastasis and TNM stages were significantly related with the QS and DFS （P〈0.05）. Conclusion： The high level of NLR before operations is an independent risk factor to influence the OS and DFS of the patients who accepted modified radical mastectomy of breast cancer.

关 键 词：乳腺肿瘤 中性粒细胞 淋巴细胞比值 外科手术 预后 

分 类 号：R737.9[医药卫生—肿瘤]