鼻-鼻颅底恶性肿瘤的治疗进展  

Advances in the treatment of sinonasal malignant tumors

作　　者：刘剑锋[1] 杨大章[1] 

机构地区：[1]中日友好医院耳鼻咽喉科,北京100029

出　　处：《中国耳鼻咽喉颅底外科杂志》2017年第6期501-508,共8页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：国家自然科学基金(30801281);人社部出国留学择优资助项目(2013-QTL-026);中日友好医院青年英才计划A类(2014-QNYC-A-02)

摘　　要：鼻腔鼻窦恶性肿瘤少见,而且病理类型繁多。针对单一病理类型的多中心的研究缺乏。鼻腔鼻窦恶性肿瘤的治疗通常以手术为主,辅助以放疗,化疗作用有限。鼻-鼻窦恶性肿瘤的总体预后不佳。本文总结鼻腔鼻窦恶性肿瘤的诊断和治疗进展,特别是内镜经鼻手术在切除鼻腔鼻窦颅底恶性肿瘤中的应用,以及放疗、化疗和靶向治疗多学科综合治疗的进展。介绍鼻腔鼻窦恶性肿瘤的评估和治疗策略以及随访的规范建议。Sinonasal malignant tumors are rare, and have a variety of histopathologies. Multicenter investigation on specific histopathology is paucity. Multimodality treatment with surgery and postoperative radiation therapy is the standard paradigm. The effect of chemotherapy is limited in the management of sinonasal malignancies. Overall survival for sinonasal malignancies remains poor. This paper reviews the progress of diagnosis and treatment in sinonasal malignant tumors in the past decade, including endoscopic endonasal approaches, radiation therapy, chemotherapy as well as targeted therapy. Recommendations on evaluation, treatment strategies, and surveillance are presented.

关 键 词：鼻腔鼻窦恶性肿瘤 治疗 手术 内镜经鼻手术 放疗 化疗 靶向治疗 

分 类 号：R739.62[医药卫生—肿瘤]