中人氟安对巨块型宫颈癌的新辅助化疗疗效分析  

Clinical analysis of neoadjuvant chemotherapy for human patients with giant cervical cancer

作　　者：李町希 梁东霞 杨晓霞 李雷 晁宏图 

机构地区：[1]郑州大学附属肿瘤医院,450000

出　　处：《辽宁医学杂志》2017年第6期28-29,43,共3页Medical Journal of Liaoning

摘　　要：目的探讨氟尿嘧啶缓释植入剂对巨块型宫颈癌患者的新辅助化疗疗效及安全性。方法收集2015年2月至2017年4月我院36例接受新辅助化疗的巨块型宫颈癌患者:17例行多西他赛+奈达铂(TP)+中人氟安方案新辅助化疗,19例行TP方案新辅助化疗。对比两组之间化疗有效率、术中情况、术后病理特征及不良反应的差异。结果观察组近期化疗有效率94.11%,高于对照组的63.16%,差异有统计学意义(P<0.05),术中情况、术后病理特征及不良反应与对照组无统计学差异(P>0.05)。结论氟尿嘧啶缓释植入剂对局部晚期宫颈癌具有较好的疗效,不增加手术并发症发生率和药物不良反应发生率。Objective To investigate the efficacy and safety of fluorouracil sustained-release implants in neoadjuvant chemotherapy in patients with giant cervix.Methods From February 2015 to April 2017,36 patients with neoadjuvant chemotherapy were enrolled in this study.17 patients with docetaxel ＋ nedaplatin（TP） ＋ human fenfloxacin neoadjuvant chemotherapy,19 cases of TP regimen neoadjuvant chemotherapy.Comparison of the two groups between the efficacy of chemotherapy,intraoperative,postoperative pathological features and adverse reactions.Results The effective rate of chemotherapy was 94.11% in the observation group and 63.16% higher than that in the control group（P〈0.05）.There was no significant difference between the two groups（P〉0.05）.There was no significant difference between the two groups（P〉0.05）.Conclusion Fluorouracil sustained-release implants have a good effect on locally advanced cervical cancer,without increasing the incidence of surgical complications and the incidence of adverse drug reactions.

关 键 词：氟尿嘧啶缓释植入剂 宫颈癌 新辅助化疗 

分 类 号：R737.33[医药卫生—肿瘤]