Synergistic effects of a curcumin analogue and docetaxel on growth inhibition of human prostate cancer cells  

姜黄素类似物和多西紫杉醇对人前列腺癌细胞生长的协同作用(英文)

作　　者：周代营[1] 丁立[1] 王希[1] 马娟[1] 黄沃林 Susan Goodin 郑希 

机构地区：[1]广东食品药品职业学院,广东广州510520 [2]美国新泽西罗格斯癌症研究所 [3]美国罗格斯大学苏珊Lehman Cullman癌症研究所

出　　处：《Journal of Chinese Pharmaceutical Sciences》2017年第11期827-833,共7页中国药学（英文版）

基　　金：The National Cancer Institute of China(Grant No.P30-CA072720);the National Natural Science Foundation of China(Gr ant No.81272452);the PhD Start-up Fund of Natural Science Foundation of Guangdong Province,China(Grant No.2014A030310329)

摘　　要：Cancer of the prostate gland is a leading cause of death. In the present study, we studied the effects and mechanisms of curcumin analogue E10, docetaxel or their combination on prostate cancer （PC）-3 cells. Treatment of PC-3 cells with El0 or docetaxel resulted in growth inhibition in a concentration-reliant fashion. Combinations of E10 and docetaxel inhibited the growth of PC-3 cells in a synergistic manner. Effects of a combination of E10 and docetaxel were associated with synergistic inhibition of the transcriptional activity of nuclear factor-kappa B （NF-KB）, and robust reductions in the levels of B-cell lymphoma-2 （Bcl-2） were found in PC-3 cells treated with a combination of E10 and docetaxel. Our data indicated that the effects of El0 in combination with docetaxel on PC-3 cells were associated with inhibition of NF-r,B and Bcl-2. Further studies using suitable animal models are necessary to determine the in vivo effect of this combination.前列腺癌是发生于男性前列腺组织中的恶性肿瘤,近年来我国前列腺癌发病率迅速上升。本文以前列腺癌细胞PC-3细胞株为主要研究对象,联合姜黄素类似物E10和多西紫杉醇作用于前列腺癌细胞,比较其与单独给药的作用效果。结果显示低剂量的姜黄素类似物E10与低剂量的多西紫杉醇联合使用,比两种药物单独高剂量使用更能有效地抑制前列腺癌细胞生长,核转录因子NF-κB信号传导通路和Erk1/2传导通路具有协同作用的机制。研究结果表明联合姜黄素类似物E10和多西紫杉醇对抑制前列腺癌细胞具有一定的协同效应。

关 键 词：Combination treatment Prostate cancer Curcumin analogue DOCETAXEL Synergistic effect 

分 类 号：R96[医药卫生—药理学]