受体酪氨酸激酶EphB6在胃癌中的表达及其临床意义  

Expression of receptor tyrosine kinase EphB6 in gastric cancer and its clinical significance

作　　者：陈昌浩[1] 孙岳军 

机构地区：[1]东南大学附属第二医院肝胆外科,南京210003 [2]东南大学医学院附属江阴医院病理科,214400

出　　处：《临床肿瘤学杂志》2017年第12期1111-1115,共5页Chinese Clinical Oncology

摘　　要：目的探讨受体酪氨酸激酶EphB6在胃癌组织中的表达及与临床病理特征的关系。方法采用免疫组织化学技术检测152例胃癌和癌旁组织中EphB6蛋白的表达,并分析其表达与胃癌临床病理特征的关系。结果 152例胃癌组织中,EphB6低表达66例(43.4%),中等强度表达54例(35.5%),高表达32例(21.1%);EphB6在癌旁组织中呈高表达。EphB6蛋白表达与分化程度、淋巴结转移及TNM分期有关(P<0.05),而与年龄、性别、肿瘤部位和浸润深度均无关(P>0.05)。结论 EphB6在胃癌组织中表达下调,且与淋巴结转移有关,其可能是预测胃癌转移的潜在指标。Objective To explore the expression of receptor tyrosine kinase EphB6 in gastric cancer tissues and its relationship with clinicopathological characteristics.Methods The expression of EphB6 in 152 gastric cancer and paired adjacent normal tissues was detected by immunohistochemistry.The relationship between the expression of EphB6 and clinicopathological parameters was analyzed.Results In 152 cases of gastric cancer,the low expression of EphB6 was found in 66 cases（43.4%）,moderate expression in 54 cases（35.5%）,and high expression in 32 cases（21.1%）.The expression of EphB6 was high expressed in adjacent normal tissues.The expression of EphB6 was associated with differentiation,lymph node metastasis and TNM stage（P〈0.05）,but not related to age,gender,tumor location and depth of tumor invasion（P〈0.05）.Conclusion The expression of EphB6 protein was decreased in gastric cancer and related to lymph node metastasis.It may be a potential marker to predict the metastasis of gastric cancer.

关 键 词：胃癌 EphB6 受体酪氨酸激酶 转移 

分 类 号：R735.2[医药卫生—肿瘤]