六溴环十二烷异构体的毒理效应及其在生物体内的代谢转化过程研究进展  

Toxicological effects and metabolic transformation of hexabromocyclododecane isomers in organisms:A review

作　　者：耿金瑶 王莹莹[2,3,1] 

机构地区：[1]南开大学环境科学与工程学院,天津300350 [2]天津市城市生态环境修复与污染防治重点实验室,天津300350 [3]环境污染过程与基准教育部重点实验室,天津300350

出　　处：《环境化学》2017年第12期2558-2566,共9页Environmental Chemistry

基　　金：国家重点基础研究发展计划(2015CB459000)资助~~

摘　　要：六溴环十二烷(hexabromocyclododecane,HBCD)是一种溴化阻燃添加剂,在建筑、纺织、电子生产等工业中被广泛应用,造成环境污染的同时,对人体健康也存在危害,属于持久性有机污染物(POPs),引起各国学者的广泛关注.工业级的HBCD主要由(±)-α-HBCD,(±)-β-HBCD和(±)-γ-HBCD构成,本文总结了近年来关于HBCD对映异构体及非对映异构体的研究,对比几种异构体的毒理效应、在不同生物体内的吸收、转化、代谢的过程及其代谢机理,发现几种异构体对不同种生物体甚至同一种生物体不同组织部位的作用均存在很大差异,提出了进一步研究的主要方向.Hexabromocyclododecane（HBCD） is a brominated flame retardant（BRFs） that is widely used in construction,textile,electronic manufacturing and other industries.It has been classified as a persistent organic pollutant（POPs） and poses a potential threat to humans.HBCD contamination in different environments has drawn considerable attention from researchers all over the world.Industrial HBCD is mainly composed of the（±）-α-HBCD,（±）-β-HBCD and（±）-γ-HBCD isomers.This review summarizes recent studies on HBCD enantiomers and diastereomers,and further compares the differences in their toxicological effects,absorption,transformation,metabolism and metabolic mechanisms in various organisms.The HBCD isomers were found to exhibit differential effects on various species,even on disparate tissues in the same organism.Future research directions in this field are also proposed in this review.

关 键 词：六溴环十二烷 毒理效应 转化 代谢 生物体 

分 类 号：X171.5[环境科学与工程—环境科学]