微波法碳量子点制备及用作盐酸雷尼替丁的探针  

The preparation of carbon quantum dots by microwave and its application as a probe for ranitidine hydrochloride

作　　者：孙雪花[1] 李浩[1] 李丽 高楼军[1] 孙荣 

机构地区：[1]延安大学化学与化工学院,反应工程省级重点实验室,延安716000

出　　处：《分析试验室》2018年第1期46-49,共4页Chinese Journal of Analysis Laboratory

基　　金：陕西省教育厅专项科研基金(15JK1828)、陕西省延安市科技计划项目(2015KG-05)和延安大学校级科研项目(YD2016-10)资助

摘　　要：以抗坏血酸为碳源,采用微波法合成的稳定性高,水溶性好的发光碳量子点。在pH 5.00的B-R的缓冲溶液中,基于盐酸雷尼替丁对碳量子点的荧光猝灭作用,建立了一种检测盐酸雷尼替丁的新方法。实验发现,盐酸雷尼替丁浓度在1.0~7.0μmol/L和0.1~1.0μmol/L范围内与碳量子点的荧光猝灭强度呈现良好的线性关系,检出限为71 nmol/L。方法用于胶囊及血样中盐酸雷尼替丁含量的测定,其回收率分别为96.4%~99.0%和96.0~106.0%。Taking ascorbic acid as carbon source, L-lysine as passivating agent, microwave method was used to synthesize luminescent carbon quantum dots, in citric acid / sodium citrate buffer solution （ pH 5.00 ） . The reaction between carbon quantum dots and ranitidine hydrochloride capsules can quench the fluorescence of carbon quantum dots regularly. Based on this phenomenon, a new method that for determining ranitidine hydrochloride was established, in which carbon quantum dots was used as the fluorescent probe. The concentration of ranitidine hydrochloride presented a nice linear relationship with the fluorescence intensity from 1.0 ~ 70 μmol/L and 0. 1 - 1.0μmol/L, and the detection limit was 71 nmol/L. The method was applied to analyze the ranitidine hydrochloride content in drugs and blood samples, and the recovery was from 96. 4% to 99.0% and 96.0% to 106.0%, respectively.

关 键 词：盐酸雷尼替丁 碳量子点 猝灭 荧光强度 

分 类 号：R917[医药卫生—药物分析学] O657.3[医药卫生—药学]