NGF对视神经挫伤患者视力和VEP的影响及安全性分析  

Improvement of visual acuity and VEP after optic nerve contusion by NGF and its safety analysis

作　　者：赵明 

机构地区：[1]中国河南省信阳市中心医院眼科,464000

出　　处：《国际眼科杂志》2018年第2期316-318,共3页International Eye Science

摘　　要：目的:探讨鼠神经生长因子(NGF)对视神经挫伤患者视力、视觉诱发电位(VEP)的影响。方法:选取2013-01/2016-06视神经挫伤患者78例78眼,根据随机数字表法分为观察组和对照组各39例39眼,两组均给予醋酸泼尼松片、维生素及甲钴胺片治疗,观察组同时给予NGF治疗,连续治疗2个疗程(21d为一个疗程)。结果:治疗前两组患者的视野缺损度、视野光敏感度差异无统计学意义(P>0.05);治疗后,观察组的视野缺损度范围小于对照组(P<0.05),观察组的视野光敏感度显著高于对照组(P<0.05);治疗前,两组患者的P100波潜伏期、P100波振幅差异无统计学意义(P>0.05);治疗后,观察组患者的P100波潜伏期小于对照组(P<0.05)、观察组的P100波振幅显著高于对照组(P<0.05);治疗后,观察组的视力显著优于对照组(P<0.05)。结论:NGF治疗视神经挫伤能显著地改善患者视力、VEP指标,减小视野缺损。AIM：To investigate the effect of neuropathic factor（NGF）on visual acuity and visual evoked potential（VEP）in patients with optic nerve contusion.METHODS：Totally 78 patients（78 eyes）with optic nerve contusion were selected. From January 2013 to June 2016, 39 cases（39 eyes）were divided into observation group and control group respectively according to the random number table method. Prednisone, vitamins and mecobalamin tablets treatment were given to both groups, based on that, the observation group was given NGF treatment, continuous treatment of 2 courses（21d for a course of treatment）.RESULTS： There was no significant difference in visual field defect and visual field sensitivity between the observation group and the control group before treatment（P〉0.05）. After treatment, the visual field defect degree of the observation group was smaller, the visual field sensitivity was better than that of the control group（P〈0.05）. There was no significant difference in P100 wave latency and P100 wave amplitude between the observation group and the control group before treatment（P〉0.05）. After treatment, the P100 wave latency of the observation group was significantly shorter than that of the control group（P〈0.05）. The amplitude of P100 wave in the observation group was higher than that in the control group（P〈0.05）. After treatment, the visual acuity and visual field sensitivity of the observation group was significantly better than that of the control group（P〈0.05）.CONCLUSION： NGF treatment for optic nerve contusion can significantly improve the patient＇s visual acuity, VEP indicators, reduce visual field defects, improve visual field sensitivity.

关 键 词：鼠神经生长因子 视神经挫伤 视力 视觉诱发电位 

分 类 号：R774.6[医药卫生—眼科]