老年脑卒中后抑郁与血清同型半胱氨酸水平的相关性研究  

Study on the Correlation Between Post-stroke Depression and Serum Homocysteine Level in Elderly Patients

作　　者：杨克俊[1] 周爱泉 鄢圣娟 胡成伍[1] 田一峰 田亮[1] 王兆薇 YANG Kejun;ZHOU Aiquan;YAN Shengjuan;HU Chengwu;TIAN Yifeng;TIAN Liang;WANG Zhaowei(Neurology Department, Qianjiang City Center Hospital, Qianjiang Hubei 433199, China;Surgery Department)

机构地区：[1]湖北省潜江市中心医院神经内科,湖北潜江433199 [2]湖北省潜江市中心医院外科,湖北潜江433199

出　　处：《中国继续医学教育》2017年第34期65-66,共2页China Continuing Medical Education

摘　　要：目的研究老年脑卒中后抑郁与血清同型半胱氨酸水平的相关性。方法选择2015年6月—2017年1月本院收治的110例脑卒中患者作为研究对象。根据抑郁情况,将患者分为两组,采血检测患者血浆Hcy水平,对比两组患者血浆Hcy水平。结果在血浆Hcy水平方面,观察组患者血浆Hcy水平平均值高于对照组患者,差异具有统计学意义(P<0.05);在抑郁症患者血浆Hcy水平方面,观察组中,轻、中、重度患者血浆Hcy水平对比,差异具有统计学意义(P<0.05),患者血浆Hcy水平越高,患者抑郁症越严重。结论老年脑卒中后抑郁与血清同型半胱氨酸水平呈正相关,血清同型半胱氨酸水平越高,患者抑郁情况越严重,降低患者血清同型半胱氨酸水平,对于抑郁症的治疗可以起到很好的帮助作用。Objective To study the correlation between senile post-stroke depression and serum homocysteine levels. Methods A total of 110 patients with cerebral apoplexy were enrolled in this study from June 2015 to January 2017. Patients were divided into two groups according to the depressive situation. Plasma Hcy levels were measured in blood samples, and plasma Hcy levels were compared between the two groups. Results The average plasma Hcy levels in the observation group were signifcantly higher than those in the control group, the difference was statistically signifcant （P〈0.05）. Plasma Hcy levels in the patients with mild, moderateand severe groups were significantly different （P〈0.05）, the higher the plasma Hcy level, the more severe the depression. Conclusion There is a positive correlation between senile post-stroke depression and serum homocysteine level. The higher the plasma Hcy level, the more serious the depression, reducing the serum homocysteine levels has a very good help for the treatment of depression.

关 键 词：老年脑卒中 抑郁 血清同型半胱氨酸 相关性 研究 

分 类 号：R743[医药卫生—神经病学与精神病学]