缺血性脑血管病病人血尿酸水平与颈动脉粥样硬化斑块的关系  

Relationship between Serum Uric Acid Level and Carotid Plaque in Patients with Ischemic Cerebrovascular Disease

作　　者：孟胜喜[1] 霍清萍[1] 王兵[1] 彭文波[1] 王宇新[1] 梁芳[1] 汪天湛[1] Meng Shengxi;Huo Qingping;Wang Bing;Peng Wenbo;Wang Yuxin;Liang Fang;Wang Tianzhan(Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, Chin)

机构地区：[1]上海交通大学附属第六人民医院,上海200233

出　　处：《中西医结合心脑血管病杂志》2018年第1期37-39,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：上海市科委中医类引导项目(No.15401933300);上海市卫计委项目(No.YSNXD-YL-YSZK013)

摘　　要：目的探讨缺血性脑血管病(ICVD)病人血尿酸(SUA)水平与颈动脉粥样硬化(CAS)斑块之间的相关性。方法选取上海市第六人民医院2014年12月—2016年6月门诊及住院治疗的40岁~80岁ICVD病人510例,检测其外周SUA和血脂水平。超声检查颈动脉斑块,将其分为斑块组(268例)和无斑块组(242例),对影响斑块发生的因素进行多因素Logistic回归分析,并按照斑块性质将其分为稳定斑块组和不稳定斑块组,比较各组间SUA水平差异。结果斑块组、无斑块组病人年龄、肥胖发生率及总胆固醇(TC)、SUA水平比较,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,年龄、肥胖、TC、SUA与CAS斑块有密切关系。与无斑块组比较,不稳定斑块组SUA水平显著升高,差异有统计学意义(P<0.05),稳定斑块组SUA水平变化不大,差异无统计学意义(P>0.05);与稳定斑块组比较,不稳定斑块组SUA水平明显升高,差异有统计学意义(P<0.05)。结论高龄、肥胖及TC、SUA水平升高是ICVD病人CAS斑块形成的危险因素,ICVD病人SUA水平升高与CAS斑块的发生及斑块性质有关,与不稳定斑块有密切的关系。Objective To investigate the relationship between serum uric acid（SUA）level and carotid plaque in patients with ischemic cerebrovascular disease（ICVD）.Methods Five hundreds and ten ICVD patients（aged from40 to 80 years old）among out-patients and in-patients of Shanghai Sixth People＇s Hospital from December 2014 to June 2016 were sellected as study subjects.The levels of SUA and blood lipid were measured.According to the results of carotid artery ultrasound,the patients were divided into plaque group（P group）and plaque-free group（PF group）.There were 268 patients in P group and242 patients in PF group.The multivariate logistic regression analysis was performed to assess the factors affecting the occurrence of plaque.The patients were also divided into unstable plaque group（UP group）and stable plaque group（SP group）according to the nature of plaque.SUA level of each group was compared with others.Results There were significant differences in age,obesity prevalence,total cholesterol（TC）and SUA levels between the two groups（P〈0.05）.The multiple logistic regression analysis showed that age,obesity,TC,SUA were independent risk factors for the incidence of carotid plaques.There were significant differences in SUA levels between PF group and UP group（P0.05）,between SP group and UP group（P〈0.05）.Conclusion The high level of SUA was significantly correlated with the occurrence of carotid plaques,and the higher SUA levels have a significant relationship with unstable carotid plaque in ICVD patients.Old age,obesity,high levels of TC and SUA are risk factors for the occurrence of carotid plaque.

关 键 词：缺血性脑血管病 血尿酸 颈动脉斑块 血脂 肥胖 

分 类 号：R743[医药卫生—神经病学与精神病学] R255.2[医药卫生—临床医学]